Detailed information of TA system TA152686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2626..3206
• Replicon: plasmid unnamed4
• Accession: NZ_CP050352
• Organism: Klebsiella pneumoniae strain ZRKP02

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8J3DTL7
• Locus tag: HB787_RS29155
• Protein ID: WP_071177730.1
• Coordinates: 2892..3206 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X1PRM1
• Locus tag: HB787_RS29150
• Protein ID: WP_000093040.1
• Coordinates: 2626..2904 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB787_RS29135	1199..1444	+	246	WP_032440458.1	hypothetical protein	-
HB787_RS29140	1718..2089	+	372	WP_001237044.1	cell envelope integrity protein TolA	-
HB787_RS29145	2086..2292	+	207	Protein_3	TonB family protein	-
HB787_RS29150	2626..2904	+	279	WP_000093040.1	CopG family ribbon-helix-helix protein	Antitoxin
HB787_RS29155	2892..3206	+	315	WP_071177730.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HB787_RS29160	3370..3798	+	429	WP_001140599.1	hypothetical protein	-
HB787_RS29165	3824..4003	+	180	WP_000165970.1	Rop family plasmid primer RNA-binding protein	-
HB787_RS29170	4030..4560	-	531	WP_071177729.1	hypothetical protein	-
HB787_RS29175	4567..5298	-	732	WP_071177728.1	replication-relaxation family protein	-
HB787_RS29180	5298..7262	-	1965	WP_071177727.1	TraM recognition domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..10060	10060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11805.73 Da
• Isoelectric Point: 9.8324

>T152686 WP_071177730.1 NZ_CP050352:2892-3206 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Nucleotide

• Length: 315 bp

>T152686 NZ_CP066389:500131-500472 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10709.73 Da
• Isoelectric Point: 4.7561

>AT152686 WP_000093040.1 NZ_CP050352:2626-2904 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Nucleotide

• Length: 279 bp

>AT152686 NZ_CP066389:499901-500131 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Antitoxin

• AlphaFold DB: A0A2X1PRM1