Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4160279..4160898 Replicon chromosome
Accession NZ_CP050342
Organism Klebsiella pneumoniae strain ZRKP03

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HB788_RS20605 Protein ID WP_002892050.1
Coordinates 4160680..4160898 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HB788_RS20600 Protein ID WP_002892066.1
Coordinates 4160279..4160653 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB788_RS20590 4155431..4156624 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HB788_RS20595 4156647..4159793 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HB788_RS20600 4160279..4160653 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HB788_RS20605 4160680..4160898 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HB788_RS20610 4161057..4161623 + 567 WP_002892030.1 maltose O-acetyltransferase -
HB788_RS20615 4161595..4161735 - 141 WP_004147370.1 hypothetical protein -
HB788_RS20620 4161756..4162226 + 471 WP_002892026.1 YlaC family protein -
HB788_RS20625 4162201..4163652 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HB788_RS20630 4163753..4164451 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HB788_RS20635 4164448..4164588 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HB788_RS20640 4164588..4164851 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T152652 WP_002892050.1 NZ_CP050342:4160680-4160898 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T152652 NZ_CP066366:c4233860-4233687 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT152652 WP_002892066.1 NZ_CP050342:4160279-4160653 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT152652 NZ_CP066366:c4234184-4233888 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References