Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4878835..4879351 Replicon chromosome
Accession NZ_CP050336
Organism Klebsiella pneumoniae strain ZRKP04

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HB789_RS24050 Protein ID WP_002886902.1
Coordinates 4878835..4879119 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HB789_RS24055 Protein ID WP_002886901.1
Coordinates 4879109..4879351 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB789_RS24025 4874319..4874627 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HB789_RS24030 4874712..4874885 + 174 WP_002886906.1 hypothetical protein -
HB789_RS24035 4874888..4875631 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HB789_RS24040 4875988..4878126 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HB789_RS24045 4878367..4878831 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HB789_RS24050 4878835..4879119 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB789_RS24055 4879109..4879351 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HB789_RS24060 4879429..4881339 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HB789_RS24065 4881362..4882516 - 1155 WP_002886900.1 lactonase family protein -
HB789_RS24070 4882582..4883322 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T152631 WP_002886902.1 NZ_CP050336:c4879119-4878835 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T152631 NZ_CP066366:184302-184409 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT152631 WP_002886901.1 NZ_CP050336:c4879351-4879109 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT152631 NZ_CP066366:c184254-184188 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References