Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4162852..4163471 Replicon chromosome
Accession NZ_CP050336
Organism Klebsiella pneumoniae strain ZRKP04

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HB789_RS20625 Protein ID WP_002892050.1
Coordinates 4163253..4163471 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HB789_RS20620 Protein ID WP_002892066.1
Coordinates 4162852..4163226 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB789_RS20610 4158004..4159197 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HB789_RS20615 4159220..4162366 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HB789_RS20620 4162852..4163226 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HB789_RS20625 4163253..4163471 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HB789_RS20630 4163630..4164196 + 567 WP_002892030.1 maltose O-acetyltransferase -
HB789_RS20635 4164168..4164308 - 141 WP_004147370.1 hypothetical protein -
HB789_RS20640 4164329..4164799 + 471 WP_002892026.1 YlaC family protein -
HB789_RS20645 4164774..4166225 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HB789_RS20650 4166326..4167024 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HB789_RS20655 4167021..4167161 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HB789_RS20660 4167161..4167424 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T152629 WP_002892050.1 NZ_CP050336:4163253-4163471 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T152629 NZ_CP066361:482023-482196 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT152629 WP_002892066.1 NZ_CP050336:4162852-4163226 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT152629 NZ_CP066361:481697-482026 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References