152611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4463068..4464326 Replicon chromosome
Accession NZ_CP050335
Organism Pseudomonas aeruginosa strain DVT401

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HB725_RS20690 Protein ID WP_003163133.1
Coordinates 4463068..4463823 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag HB725_RS20695 Protein ID WP_003086329.1
Coordinates 4463958..4464326 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB725_RS20680 4458245..4460788 + 2544 WP_174816558.1 acyl-homoserine-lactone acylase QuiP -
HB725_RS20685 4460944..4462305 - 1362 WP_003081943.1 DNA recombination protein RmuC -
HB725_RS20690 4463068..4463823 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
HB725_RS20695 4463958..4464326 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
HB725_RS20700 4464399..4465685 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
HB725_RS20705 4465741..4467330 - 1590 WP_078452049.1 aldehyde dehydrogenase family protein -
HB725_RS20710 4467409..4467885 + 477 WP_003112531.1 hypothetical protein -
HB725_RS20715 4467888..4468163 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T152611 WP_003163133.1 NZ_CP050335:c4463823-4463068 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T152611 NZ_CP066355:c8256712-8255789 [Bradyrhizobium diazoefficiens]
ATGATCGGCAAGCCGCTCAAAGATCCCGGTGCTTCGATCCGTCAGCGCCTGCTCAACCACGCCAAGGAGCACGGCGACGA
GTATCAACGGATTCTGACGCGCTACGCGATTGAGCGGTTGCTTTTCAGACTAAGCCAAACCGAGGCGCGCGAGCGATACG
TCCTCAAGGGCGCGATGCTCTTCGTGACTTGGCCCGAACAAGTGTTTCGGCCCACAGGTGATCTTGACCTTCTTGGGCAA
GGGGATCCCGATCCAGCTGCCATCATCGATCTCTTCACCCTTATCTGCCAGGTCGAGGCGCCGGCGGATGGCATCATCTT
CGACCCCTCTACGCTGCAGGTGGAGGCGGTCCGCGAGGAGGAAAAATATCAGGGTGTCAGACTCTCCCTGAGGGGACGTC
TTGGCACGGCGGTGATCCCTGTCCAGGTGGACATCGGGTTTGGGGACAGTGTTCATCCCGCGCCCAGCCGGAACAATTTC
CCCAGCCTGCTGCCGGACCTGCCGGCGGCGGACGTCCTGATGTACCCGCCCGAGACAGTAATTGCAGAGAAATTCGAAGC
GATGATCCGCTTTGGCGAAGCGAACGGCAGGATCAAAGATTTTCACGATATCTGGGTCACGGCGCGAACCTTCGCTTTCA
ACCTCTCTACGCTGGTCGAGGCGGTTAGCGGTACCCTGCAAAGGCGGGAAACCGCGTTCCCGACGGAGATGCCGGTGGCG
CTGACGTCTCAGTTCGCCGAGATGGCCGACAAACAAGCGCTATGGACAGGCTTTCTGCGCCGCAATCCGCCCACGCTGCC
GCCGCCTCCATTGGGCGACTTGTTGGCGGAGCTGCGGCGGTTCTTCGAACCCGTGCTTGCGGCTCTTCCTTTGCCGGAAA
GCGCGACCGGTCGTTGGAATCCGGACCGCGGCGCCTGGGAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT152611 WP_003086329.1 NZ_CP050335:c4464326-4463958 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT152611 NZ_CP066355:c8257401-8256709 [Bradyrhizobium diazoefficiens]
ATGACATCAGCTGCTAATCTTCAAATGTTGTTCAATGTCGACAAATCTGCTGACGTGCCGACAAAAGATAACAAAATGAC
CCAACGTCATGTGCTGCCTTATCGCGAGCGCGCCCTCAATCTCGTTCGGGCTCGAGGCATTGCCCGCGCCCGCGACTTCA
AAGCCGCGGGTATCCCCCTTGTTTACCTGAAGCGACTGACAGACACAGGTGAACTCGTTCGACTTGGAAGAGGGCTCTAC
CAAGATCCGGATCGAGTCGGAGAAGATGTCGCTCATAATCTTGCGGAAGCCGCACGGGCCGTTCCCAACGGAGTCGTTAG
CCTTGCCAGTGCGCTCCGGTACCACGGGTTGACGACCCAGCTGCCGCATGCCGTCTGGCTGACCATTCCGCACAAAGCTA
GAACTCCGAAGGCCATTGGCTTCCCGTTGGAAATCGTCCGCGCCACAGGCGATGTGATGACAGCTGGCGTCGAGCATGTG
CAGGTCGAAGGCGTCGACGTCCCCATATACGGCGTAGCTAAAACCATCGCCGATTGCTTCAAGCACCGTCGTCATATCGG
GGAGGACGTCGCGATCGAGGCACTCCGCGATGCGCTCCGCCTGCGGAAGACTACAGTGAGCGATGTCATGAGGTACGCCG
AGATCGATCGTGTGGCCGAGAGAATCCGCCCCGTTCTTAAGGCGCTTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References