Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3516504..3517725 Replicon chromosome
Accession NZ_CP050335
Organism Pseudomonas aeruginosa strain DVT401

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB725_RS16240 Protein ID WP_003114949.1
Coordinates 3517147..3517725 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB725_RS16235 Protein ID WP_003088112.1
Coordinates 3516504..3517058 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB725_RS16210 3512072..3512623 + 552 WP_003102727.1 XRE family transcriptional regulator -
HB725_RS16215 3512620..3513018 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HB725_RS16220 3513031..3513354 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HB725_RS16225 3513685..3514146 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB725_RS16230 3514151..3516346 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB725_RS16235 3516504..3517058 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HB725_RS16240 3517147..3517725 + 579 WP_003114949.1 HD domain-containing protein Toxin
HB725_RS16245 3517833..3519020 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB725_RS16250 3519010..3521181 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
HB725_RS16255 3521171..3522448 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152610 WP_003114949.1 NZ_CP050335:3517147-3517725 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152610 NZ_CP066355:6875420-6875845 [Bradyrhizobium diazoefficiens]
GTGAACCTGCTGCTCGACACCAACATACTGTCGGAAGTTCAGCGGCCAGCCCCCTCGCCGAATGTCTTGGCTTGGCTTGA
CACGATCGATGAAGATCGTGCGTTCATCAGCGTCGCATCGATCGCCGAGCTTCGCCGCGGCATCGCATTGCTGGAGGATG
GCCGCCGGCGCTCGGCACTGGCCGCTTGGCTTGCCGATGATCTGCCGACGCGGTTTGGCGAACGTGTCCTGCCGATCGAC
CAGGCGGTGGTCGAGCGCTGGGGCGACCTGATGGCTCAGAGCCGCCGCAGCGGCGTTGCTCTGTCCGTCATGGATGGCTT
CTTTGCCGCGACCGCGCTTGCAAACGATCTCACGCTCGCCACGCGCAATGTGAAGGATTTTGCCGCATTCGGCGTCCCCC
TGCTCAATCCGTGGGACGACCGATAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152610 WP_003088112.1 NZ_CP050335:3516504-3517058 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152610 NZ_CP066355:6875139-6875423 [Bradyrhizobium diazoefficiens]
ATGGCCGATCACAACACTGCACCCGACACGCTTCCGGCTGATGACACGTGGACGCTTGCCAACGCCAAGGCACGACTGTC
CCAGGTGATCGACCGCGCCCAAACCGGCCCGCAGATCATCACCCGTCACGGCAAGCCCAATGCGGTGGTCGTTTCCGCCG
AGGAATGGGCCCGCAAGACCGCACGCAAAGGCACGTTGGCCGAATTCCTGCTGGCCTCTCCGCTGCGCGGCGCCGACCTC
GCACTTGATCGCACGCACGATGCGCCGCGCGACGAGATGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References