Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1855945..1857453 Replicon chromosome
Accession NZ_CP050335
Organism Pseudomonas aeruginosa strain DVT401

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HB725_RS08720 Protein ID WP_012613851.1
Coordinates 1855945..1856532 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HB725_RS08725 Protein ID WP_012613852.1
Coordinates 1856599..1857453 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB725_RS08715 1852200..1855679 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
HB725_RS08720 1855945..1856532 + 588 WP_012613851.1 GNAT family N-acetyltransferase Toxin
HB725_RS08725 1856599..1857453 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
HB725_RS08730 1857550..1859715 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
HB725_RS08735 1859890..1861764 + 1875 WP_003158329.1 MFS transporter -
HB725_RS08740 1861825..1862034 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T152609 WP_012613851.1 NZ_CP050335:1855945-1856532 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

>T152609 NZ_CP066355:c1464521-1463601 [Bradyrhizobium diazoefficiens]
ATGGCGCGTGAGCCTCGCAACATCGGCGCATCAGTGCGAGCGCGGCTCCTCGATCGGGCACGTGCCGAGCGATCGGACTT
CCAGATTCTCCTGACGCGATATGCGCTCGAGCGTCTGCTCTACCGGCTAAGCGCGTCGCCGCACCGCGACCGCTTCATCC
TCAAAGGTGCGATGCTCTTCGTGACCTGGATAGCCGATCCGTTTCGGCCTACGCGCGATCTGGATCTGCTTGGCCACGGC
GACCGCGACACCGAAGCCATTGCCGAAACCTTCCGGGCCATTTGTGCGCAGCCGGTCGTCGATGACGGTGTGACGTTTGA
TGTCGCAGCGCTGATGGCGACCCCGATTCGTGAGGAGCTGGAATATGGTGGCGTGCGGGTCCGCACAACGGCAACTATCG
CCGGGGCGCGTATTCCGATCCAGGTCGACATCGGTTTCGGCGACGCCATTACACCCGCGGCGGTCGAGATCGACTATCCC
ACCCTGCTGGACGCCCCAACGCCGCACCTTCGCGCATATCCGGTCGAAACAGTGGTAGCTGAGAAATTCGCAGCGCTCGT
GACGCTCGGCGTGGCCAACAGTCGGCTCAAGGATTTCTATGATCTCTGGGTAATCTCCCGAACATTCGAGCTTCGCCGGG
CCGCTCTTGCCGAGGCAATTCAGCGGACCTTCGAGCGACGCGGAACGGTCCTCCCATCCGTTGTCCCGGTCGGTCTGACC
GATGAATTCGCGGAAACATGGGCCGCCCAGTGGCGCGCCTTCCTGGAGCGCGATCGGATGGCAGCCGCACCGGATGCTTT
TGCCGTTACCGTCGCCGATCTCCGCCTCTTCTTGATGCCCCTGGTCGTCGGATTGAAAGAAGAACGAATTTGGCCGCCGA
GCGGGCCATGGTCGCCGGGAGCAGCAATCGATGAGGCATAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT152609 WP_012613852.1 NZ_CP050335:1856599-1857453 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT152609 NZ_CP066355:c1465131-1464511 [Bradyrhizobium diazoefficiens]
ATGCCGTCCACCAGCGCCCAGCGACTTCGCGCGCTCGACCTCCTGAAGACCCGAGGAATGCTCCGGCTGAAGGATTTCAT
CGCCGAAGGCATCGGCCCGGAGACGCTTGCCCGTCTTGTTCGGGAGGAGGCAGTCGTCCGCCCAGCACGTGGGCTCTATC
AACTCCCCGACGCCCACCTCGAGGCTGCCCATACCCTCGCCGAGGCAGCAGTTCTGGTTCCAAAGGGTGTGGTCTGTCTT
ACCTCGGCCCTCCAATACCACGAACTGACGCTGCAGATGCCGTCGGCTGTATGGATGGCGATCGATCGCTCCGCCTGGCG
ACCCAAGATCGATTATCCACCTATCCGGTTCGTGCGATTCACCGGATCGGCGCTTACCGAAGGGATCGAGCGTCACCGCA
TTGAGAATGTCGACGTTCCTATCACGGATCCGGCGAGGACAATTGTCGATTGCTTTCGCTACCGAACCAAGATCGGCCTT
GACGTCGCGATGGAGGGGCTGCGCGAAGGCCTCCGCCGTCGCCGATGCAAGCCGGATCAACTCTGGCATTACGCTCGCAA
GGCGCGGGTCTGGTCGGTCATGCGTCCCTACGTCGAAGCAATGGTGTCCGATGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References