Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3440989..3442210 Replicon chromosome
Accession NZ_CP050334
Organism Pseudomonas aeruginosa strain DVT410

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB727_RS15645 Protein ID WP_003114949.1
Coordinates 3441632..3442210 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB727_RS15640 Protein ID WP_003088112.1
Coordinates 3440989..3441543 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB727_RS15615 3436557..3437108 + 552 WP_003102727.1 XRE family transcriptional regulator -
HB727_RS15620 3437105..3437503 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HB727_RS15625 3437516..3437839 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HB727_RS15630 3438170..3438631 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB727_RS15635 3438636..3440831 + 2196 WP_023108900.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB727_RS15640 3440989..3441543 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HB727_RS15645 3441632..3442210 + 579 WP_003114949.1 HD domain-containing protein Toxin
HB727_RS15650 3442318..3443505 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB727_RS15655 3443495..3445666 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
HB727_RS15660 3445656..3446933 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152605 WP_003114949.1 NZ_CP050334:3441632-3442210 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152605 NZ_CP066351:c3284978-3284553 [Bradyrhizobium japonicum]
GTGAAACTGCTCCTCGACACCAACGTGCTGTCGGAGGTTCAGCGGGCGGCGCCTTCCCCGAAAGTCCTGGCATGGCTCGA
TACGGTCGATGAGGATCGCGCGTTCATCAGCGCTGCCTCGATCGCCGAGCTTCGCCGCGGCATCGCCCTGCTGGATGATG
GCCGTCGCCGCGCCGCACTGGCCGCTTGGCTCGCGCATGACCTGCCGGCTCGGTTCGCGCAGCGCATCCTGCCGATCGAC
CACGCGGTCGCCGAGCGCTGGGGCGACCTGATGGCGCAGAGCCGTCGCACCGGCGTTGCGTTGTCCGCGATGGACGGCTT
CCTTGCGGCCACCGCGTTCGCCAACAATCTCACGCTCGTCACACGCAATGTGACGGACTTCGCGGCCTTCGGCGTTCCGC
TGCTCAACCCGTGGAGCGGCGCCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152605 WP_003088112.1 NZ_CP050334:3440989-3441543 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152605 NZ_CP066351:c3285256-3284975 [Bradyrhizobium japonicum]
ATGACAGACCGCAGCTCCGCTCCCGATTCGCCGCCGACTGACACGTGGACGCTCGCCAATGCCAAGGCACGCCTGTCCGA
GGTGGTCGATCGCGCCCAAACTGGTCCCCAGATCATCACCCGACACGGCAGGCCCAATGCCGTGGTCGTTTCCGCGGATG
AATGGGCGCGAAAGACGGCGCGCAAAGGCACGCTGGCCGAATTCCTGCTGGCTTCGCCGTTGCGCGGTGCCGACCTCGAA
CTTGAACGGGTGCAGGATGAACCGCGCGACGAGATGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References