Detailed information of TA system TA152603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 143765..144270
• Replicon: chromosome
• Accession: NZ_CP050334
• Organism: Pseudomonas aeruginosa strain DVT410

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: HB727_RS00670
• Protein ID: WP_003083773.1
• Coordinates: 143765..144046 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HB727_RS00675
• Protein ID: WP_003083775.1
• Coordinates: 144043..144270 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB727_RS00645	139016..140365	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
HB727_RS00650	140414..141100	+	687	WP_003083762.1	FadR family transcriptional regulator	-
HB727_RS00655	141201..141935	+	735	WP_003117208.1	GntR family transcriptional regulator	-
HB727_RS00660	142139..142525	+	387	WP_003083767.1	aegerolysin family protein	-
HB727_RS00665	142557..143465	-	909	WP_057386940.1	LysR family transcriptional regulator	-
HB727_RS00670	143765..144046	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
HB727_RS00675	144043..144270	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HB727_RS00680	144446..145066	-	621	WP_003101226.1	hypothetical protein	-
HB727_RS00685	145167..145667	+	501	WP_057386938.1	LEA type 2 family protein	-
HB727_RS00690	145740..146081	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
HB727_RS00695	146163..147590	-	1428	WP_003083784.1	GABA permease	-
HB727_RS00700	147759..149252	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T152603 WP_003083773.1 NZ_CP050334:c144046-143765 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T152603 NZ_CP066347:31990-32391 [Xanthomonas citri pv. durantae]
ATGAAGCGGTACATGCTTGATACCAACACCGTGAGCCATCTCGTCAAGAGCCATCCGGCTGTCTCTCGACGGGTCATTGA
AGTGCCTATGACTGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCA
AACGCCTTCAGCAAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTAC
GGAAGCGTAAGAGCGGACCTAGAAAAGCAAGGTAAAGCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGA
AACGGATTCTGTCCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCT
AA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT152603 WP_003083775.1 NZ_CP050334:c144270-144043 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT152603 NZ_CP066347:31733-31993 [Xanthomonas citri pv. durantae]
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGCACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9