Detailed information of TA system TA152599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2949439..2950234
• Replicon: chromosome
• Accession: NZ_CP050333
• Organism: Pseudomonas aeruginosa strain DVT412

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HB729_RS13525
• Protein ID: WP_019486655.1
• Coordinates: 2949439..2949618 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HB729_RS13530
• Protein ID: WP_021263386.1
• Coordinates: 2949659..2950234 (+)
• Length: 192 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB729_RS13495	2945527..2946072	-	546	WP_031627904.1	terminase small subunit	-
HB729_RS13500	2946306..2946572	+	267	WP_016561971.1	DUF1883 domain-containing protein	-
HB729_RS13505	2946738..2947484	-	747	WP_016561972.1	hypothetical protein	-
HB729_RS13510	2947581..2948012	-	432	WP_170954483.1	hypothetical protein	-
HB729_RS13515	2948030..2948647	-	618	WP_023103092.1	glycoside hydrolase family 19 protein	-
HB729_RS13520	2948644..2948979	-	336	WP_003119044.1	phage holin, lambda family	-
HB729_RS13525	2949439..2949618	+	180	WP_019486655.1	type II toxin-antitoxin system HicA family toxin	Toxin
HB729_RS13530	2949659..2950234	+	576	WP_021263386.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HB729_RS13535	2950324..2951193	-	870	WP_174817649.1	hypothetical protein	-
HB729_RS13540	2951222..2951665	-	444	WP_023103091.1	RusA family crossover junction endodeoxyribonuclease	-
HB729_RS13545	2951658..2952266	-	609	WP_003103373.1	hypothetical protein	-
HB729_RS13550	2952730..2953200	-	471	Protein_2688	hypothetical protein	-
HB729_RS13555	2953203..2953775	-	573	WP_010793144.1	hypothetical protein	-
HB729_RS13560	2953879..2954370	+	492	WP_023103090.1	hypothetical protein	-
HB729_RS13565	2954629..2954814	-	186	WP_023103089.1	Cro/Cl family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2924857..2973682	48825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6605.65 Da
• Isoelectric Point: 11.1475

>T152599 WP_019486655.1 NZ_CP050333:2949439-2949618 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVTFEAGKGSHFKVTAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL

Nucleotide

• Length: 180 bp

>T152599 NZ_CP066343:c4886644-4886510 [Xanthomonas citri pv. durantae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin

Protein

• Length: 192 a.a.
• Molecular weight: 21294.78 Da
• Isoelectric Point: 8.3556

>AT152599 WP_021263386.1 NZ_CP050333:2949659-2950234 [Pseudomonas aeruginosa]
MYNFAIRFEQDDSAPGVAVFCRDLPELNSYGDTVEHALSEAVDAIETTLSLYVDQRRSIPVASAPEPEEHVVHLPAVTVA
KIALWNEMMRRGMRKADLCRVLGIAQVQGDRLVDFLHTSKMEQVESALAALEMRLVICAEPVKQPKQCKGAGCIRDRRLV
KARRLLRARLLELTESSGAFTRAPKIKKPGI

Nucleotide

• Length: 576 bp

>AT152599 NZ_CP066343:c4886871-4886719 [Xanthomonas citri pv. durantae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA