Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142673..143178 Replicon chromosome
Accession NZ_CP050333
Organism Pseudomonas aeruginosa strain DVT412

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HB729_RS00655 Protein ID WP_003083773.1
Coordinates 142673..142954 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HB729_RS00660 Protein ID WP_003083775.1
Coordinates 142951..143178 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB729_RS00630 137924..139273 + 1350 WP_079279937.1 C4-dicarboxylate transporter DctA -
HB729_RS00635 139322..140008 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB729_RS00640 140109..140843 + 735 WP_003117208.1 GntR family transcriptional regulator -
HB729_RS00645 141047..141433 + 387 WP_014602345.1 aegerolysin family protein -
HB729_RS00650 141465..142373 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB729_RS00655 142673..142954 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HB729_RS00660 142951..143178 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HB729_RS00665 143354..143974 - 621 WP_003101226.1 hypothetical protein -
HB729_RS00670 144075..144575 + 501 WP_003112629.1 LEA type 2 family protein -
HB729_RS00675 144648..144989 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB729_RS00680 145071..146498 - 1428 WP_003083784.1 GABA permease -
HB729_RS00685 146667..148160 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T152596 WP_003083773.1 NZ_CP050333:c142954-142673 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152596 NZ_CP066343:99697-99996 [Xanthomonas citri pv. durantae]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT152596 WP_003083775.1 NZ_CP050333:c143178-142951 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT152596 NZ_CP066343:99452-99709 [Xanthomonas citri pv. durantae]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References