Detailed information of TA system TA152592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4840844..4842102
• Replicon: chromosome
• Accession: NZ_CP050332
• Organism: Pseudomonas aeruginosa strain DVT413

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: HB730_RS22710
• Protein ID: WP_003086331.1
• Coordinates: 4840844..4841599 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HB730_RS22715
• Protein ID: WP_003086329.1
• Coordinates: 4841734..4842102 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB730_RS22700	4836012..4838555	+	2544	WP_058176229.1	acyl-homoserine-lactone acylase QuiP	-
HB730_RS22705	4838710..4840071	-	1362	WP_003134034.1	DNA recombination protein RmuC	-
HB730_RS22710	4840844..4841599	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
HB730_RS22715	4841734..4842102	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HB730_RS22720	4842175..4843461	-	1287	WP_003134035.1	FAD-binding oxidoreductase	-
HB730_RS22725	4843517..4845106	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
HB730_RS22730	4845185..4845661	+	477	WP_003116995.1	hypothetical protein	-
HB730_RS22735	4845664..4845939	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T152592 WP_003086331.1 NZ_CP050332:c4841599-4840844 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T152592 NZ_CP066315:c3088465-3088055 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACACAGTTTTTTTCAACCTGTGTTCATGGGGCAGTAGGCAT
GTTTTTGCTTGTTGCACCATGGGCACCGGCTCATTCAATGATATGGTTGCCACTTCTTGCGGTTGTGGTGGCTAGTTGGG
CAAAAAGCCAAAAGAACATCAGCAAAATAAAAGGGGTTGCTGTGTTGGTTAATGGTAATAAAGTCCAATGGAAAAAGAAT
GAATGGAATATTGTGAAAGCACCTTGGTTGAGCCGCTATGGCATCTTATTGTCATTAGAAGCTTTACAAGGTAAGCAACA
AAAAATTCACCTATGGGTTGCTAAAGACTCTGTTTCTGAGGAAAGTTGGCGTAATTTGAACCAATTATTACTTCAATACC
CTGATATTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT152592 WP_003086329.1 NZ_CP050332:c4842102-4841734 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT152592 NZ_CP066315:c3088712-3088446 [Providencia rettgeri]
ATGGATATTGAGAACAAGGCGCGAATTCATTGGGCTTGTCGCCGCGGTATGCGTGAGCTAGATATTTCAATCATGCCATT
TTTTGAGTATGAATATGATAGTCTGACAACCAATGATAAACAGGTGTTTGTCCGTTTATTGGAGTGTGCGGACCCTGATT
TATTTAACTGGTTAATGAATCACGGTCGCCCAGATGACGACGAGCTATTTCGTATGGTAAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7