Detailed information of TA system TA152591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3867437..3868658
• Replicon: chromosome
• Accession: NZ_CP050332
• Organism: Pseudomonas aeruginosa strain DVT413

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: HB730_RS18010
• Protein ID: WP_003110488.1
• Coordinates: 3868080..3868658 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HB730_RS18005
• Protein ID: WP_003088112.1
• Coordinates: 3867437..3867991 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB730_RS17980	3863005..3863556	+	552	WP_031685890.1	XRE family transcriptional regulator	-
HB730_RS17985	3863553..3863951	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
HB730_RS17990	3863964..3864287	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HB730_RS17995	3864618..3865079	+	462	WP_003088117.1	(2Fe-2S)-binding protein	-
HB730_RS18000	3865084..3867279	+	2196	WP_058176867.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HB730_RS18005	3867437..3867991	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
HB730_RS18010	3868080..3868658	+	579	WP_003110488.1	HD domain-containing protein	Toxin
HB730_RS18015	3868768..3869955	-	1188	WP_021264658.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HB730_RS18020	3869945..3872116	-	2172	WP_058176869.1	type I secretion system permease/ATPase	-
HB730_RS18025	3872106..3873383	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T152591 WP_003110488.1 NZ_CP050332:3868080-3868658 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T152591 NZ_CP066315:c2187679-2187218 [Providencia rettgeri]
ATGATTTTATATCGTTTGATTAAATCTGACTTTGCTCATGATGCGTGGTCCGGTCAAGGTGCTAGGTTATACGGTGGGCG
CTGGAACCATAAAGGTACGCCCGCTATCTACACATCAACAAGTATTTCATTAGCTGCTTTAGAAATTCTCGTTCATATAA
ACCAAGATACCGTGCTTAATCATTTCACTTTATTATCAATTGAGATCAACGATAGGTATGTGATGAAGCTGTCAGTAGAG
CATCTCCCTGATGATTGGCAGCGTGACCCAGCACCTACCTCCACAATGGACATAGGCACAACCTGGTTAACGAACCAAGA
CAGCCTAGCTTTAATTGTCCCTTCTTGTATTATTCCTTATGAATATAATGCCATTATTAACCCTATGCACCCGCAATTTC
AAAAAGTGACCCAAACCATTAAGCCCCTCGACTTTGCTTTTGACCCACGATTTAACCGGTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT152591 WP_003088112.1 NZ_CP050332:3867437-3867991 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT152591 NZ_CP066315:c2188137-2187676 [Providencia rettgeri]
ATGAGAAACTATATTCCAGCACTCCCAACCCAACCCACCACGCCACCTTTTAAGCCCCTATGGCGCTTTGCTGGCCTACC
CGCAGAACGTGGTATCGAACTCACTCATTTCCTACGACAAGGTCTTTCTGTTACGGTGTTAGACAACATTCAAGAATGGT
CTGGCATCAGCAAATCTGAATTACTCCGAATTTCAGGTATTAATGAGCGCAATGTGGCAAGGCGTAGAAATGCAGGTCAG
CCACTCAATGCCGATGAAAGTGAAAGAATTGCTCGCTTAGTGCGTGTATTTGATGCCGCTGTACGCTTATTCAATGGTGA
TAAGTCAATGGCAAGTGATTGGTTGAATCACCCCGTGAAAGGCTTAGGACATACGCGCCCTATAGAGTTGATTGCCACTG
AAAGTGGTGCTCTTGAAGTTATCGACCTTATTGGCCGCATTGAACACGGTGTTTTTTCATGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4