Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1903914..1905422 Replicon chromosome
Accession NZ_CP050332
Organism Pseudomonas aeruginosa strain DVT413

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HB730_RS08830 Protein ID WP_003119682.1
Coordinates 1903914..1904501 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HB730_RS08835 Protein ID WP_058176308.1
Coordinates 1904568..1905422 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB730_RS08825 1900169..1903648 - 3480 WP_003091610.1 hybrid sensor histidine kinase/response regulator -
HB730_RS08830 1903914..1904501 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
HB730_RS08835 1904568..1905422 + 855 WP_058176308.1 AraC family transcriptional regulator Antitoxin
HB730_RS08840 1905519..1907684 + 2166 WP_019484608.1 TonB-dependent receptor family protein -
HB730_RS08845 1907859..1909733 + 1875 WP_003117607.1 MFS transporter -
HB730_RS08850 1909794..1910003 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T152588 WP_003119682.1 NZ_CP050332:1903914-1904501 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T152588 NZ_CP066312:70587-70853 [Azotobacter chroococcum]
TTGGCCTGGACGATTGACTACACCCAGACGGCTCTCAACCAGCTACGCAAGCTCGACAAGCCATCCGCCCGGCGCATCCT
CGACTTCATGGAGGAGCGGGTCGCCCTGCGTGAAGATCCACGCAGTACCGGGAGGGCGCTCACCGGCCCATTGGGTGGAC
TGTGGCGCTACCGGGTGGGCGACTTCCGGGTGATTTGCGAGATCCAGGATGGCGCGTTGCGCGTCCTCGTGCTGGAGCTT
GGCAATCGGCGCGAGGTCTATCGCTAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31944.33 Da        Isoelectric Point: 7.7975

>AT152588 WP_058176308.1 NZ_CP050332:1904568-1905422 [Pseudomonas aeruginosa]
VPDEMSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHRGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT152588 NZ_CP066312:70376-70603 [Azotobacter chroococcum]
ATGCCCACCTCAATCCGACTGGCTCCCGAAATCGAGCAGCGCCTGGATTTCCTGGCCGCCAACACCGGGCGCACCAAAGC
GTACTACCTGCGCGAAATCATCGAGCGTGGTCTGGACGAGATGGAGGACTACTACCTCGCCGCCGAAGTGCTGGAGCGTG
TCCGCAAGGGGCAGGAGCAGGTGTATTCGTCGGCGGACGTAAGGAAAGACCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References