Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 149151..149656 Replicon chromosome
Accession NZ_CP050332
Organism Pseudomonas aeruginosa strain DVT413

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HB730_RS00665 Protein ID WP_003083773.1
Coordinates 149151..149432 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HB730_RS00670 Protein ID WP_003083775.1
Coordinates 149429..149656 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB730_RS00640 144402..145751 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HB730_RS00645 145800..146486 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB730_RS00650 146587..147321 + 735 WP_003083764.1 GntR family transcriptional regulator -
HB730_RS00655 147525..147911 + 387 WP_003083767.1 aegerolysin family protein -
HB730_RS00660 147943..148851 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB730_RS00665 149151..149432 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HB730_RS00670 149429..149656 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HB730_RS00675 149832..150452 - 621 WP_003101226.1 hypothetical protein -
HB730_RS00680 150553..151053 + 501 WP_003162763.1 LEA type 2 family protein -
HB730_RS00685 151126..151467 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB730_RS00690 151549..152976 - 1428 WP_003083784.1 GABA permease -
HB730_RS00695 153145..154638 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T152586 WP_003083773.1 NZ_CP050332:c149432-149151 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152586 NZ_CP066311:c224498-224100 [Azotobacter chroococcum]
ATGCTCGATACCTGCATTTGCTCGTTCATCATGCGGGAACTCCCGGAGTCGGTTTTACAGCGGCTGGCGGCAGAGGTTAG
CCAGAACAATCGCATCGTTATTTCTGCCGTCACCTACGCCGAAATGCGTTATGGCCAGATTGGCAAGAAAGCCTCAGCCA
GGCATAAAACGCTGGTCGATGAGTTCGTGAGGCGGCTAGACGCCGTGTTGCCGTGGGATCAACGTGCCGTAGATGCGACC
GTTGAGGTCATGCAAGCTCTGAGCAAGGCGGGTACGCCAATCGGCCCCAATGACACGGCTATCGCAGGTCATGCGATAGC
CTCCGGCTGTACGCTGGTGACAAACAATGTTCGTGAATTTGGCCGTGTACCTGGCCTTGTGCATGAGGACTGGGTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT152586 WP_003083775.1 NZ_CP050332:c149656-149429 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT152586 NZ_CP066311:c224743-224513 [Azotobacter chroococcum]
ATGCGTACCGTCTCTATTTTCAGGAACGGCAAGAATCAGGCGATTCGACTGCCGAACGACATGGCCTATGAAGGCGTCGG
GGAGCTGGAGATTACGCGCGAAGGTGACGTAATCACGCTTCGTCCGGTACGGCCAACGTGGCAGTCCCTAGCTGGCGTGC
CGAAAGCCGATGCCGACTTTCTACAAGAGCGCCCGACTGTTGTCGGTGATGAAGGCAGGTTCAATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References