152579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143333..143838 Replicon chromosome
Accession NZ_CP050331
Organism Pseudomonas aeruginosa strain DVT414

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HB731_RS00665 Protein ID WP_003083773.1
Coordinates 143333..143614 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HB731_RS00670 Protein ID WP_003112628.1
Coordinates 143611..143838 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB731_RS00640 138584..139933 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HB731_RS00645 139982..140668 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB731_RS00650 140769..141503 + 735 WP_003115036.1 GntR family transcriptional regulator -
HB731_RS00655 141707..142093 + 387 WP_014602345.1 aegerolysin family protein -
HB731_RS00660 142125..143033 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB731_RS00665 143333..143614 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HB731_RS00670 143611..143838 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HB731_RS00675 144014..144634 - 621 WP_003101226.1 hypothetical protein -
HB731_RS00680 144735..145235 + 501 WP_003112629.1 LEA type 2 family protein -
HB731_RS00685 145308..145649 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB731_RS00690 145731..147158 - 1428 WP_003083784.1 GABA permease -
HB731_RS00695 147327..148820 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T152579 WP_003083773.1 NZ_CP050331:c143614-143333 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152579 NZ_CP066311:c27856-27338 [Azotobacter chroococcum]
ATGTCGCTGACCGCGCCCCATGCGCTGGATGCCAGCCATTCACTGGAGGGGTTCGATTGCGGCAAACCGAGCCTGGATGA
TTGGCTGACGCGCCATGCCCGGCAGGCGCAGGCCAGCGGTTCGGCCAAGACCTACGTGGTCACTGACGGCGTGCGTGTCG
CGGGGTACTACAGCCTCACTGTGGGGCAGATCGATACCTTGGAAGCTCCCGCTCGTGTCCGCCAGGGCATGGGGGCTTAC
CCCATACCCGTTGTCATCCTGGCGCGGCTGGCCGTAGCCCAGCGAGACCAAGGGCTCGGAATTGGAGTCGGCCTGTTGCA
GGACGCGATCCGGCGTACCCTCACCATCGCCGAGCAGGCCGGCGTTCGAGCGCTGCTGACGCATCCGATCGACGAGGAGG
CATCACGCTTCTACCTGCGCTTTGGCTTTGAAGCATCTCCTGCTCGTGAACAGCAATTGCTGTTGCTGCTCAAGGACGCG
CGTCGGCTGCTTGCTCCGCCGACGTCACCCAGGGGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT152579 WP_003112628.1 NZ_CP050331:c143838-143611 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT152579 NZ_CP066311:c28131-27856 [Azotobacter chroococcum]
ATGGCAAGTACCACCCGTTCTGCGCGCCTTGGGTTGCGCGCCACGCCGCAGCAGGAAGCGGTGCTGCGCCGCGCGGCCGA
GGTGGCAAACAAATCGATGACCGATTTCATTCTCGACAGTGCCTGCCTGGCCGCCGAGCAGACCTTGCTCGATCAACGCC
TGTTTCTGGTGTCCGGCAGCCAGTCCCAAGCCTTGCTGGATATGCTGGATCGGCCTGCCCAGGACAATCCAGGCCTGAAG
GATTTGTTCTCGCGATCGGCACCTTGGGACAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References