152575

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3580150..3581371 Replicon chromosome
Accession NZ_CP050330
Organism Pseudomonas aeruginosa strain DVT779

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB733_RS16585 Protein ID WP_003114949.1
Coordinates 3580793..3581371 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB733_RS16580 Protein ID WP_003088112.1
Coordinates 3580150..3580704 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB733_RS16555 3575718..3576269 + 552 WP_033988797.1 XRE family transcriptional regulator -
HB733_RS16560 3576266..3576664 - 399 WP_033988799.1 NADH-quinone oxidoreductase subunit A -
HB733_RS16565 3576677..3577000 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HB733_RS16570 3577331..3577792 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB733_RS16575 3577797..3579992 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB733_RS16580 3580150..3580704 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HB733_RS16585 3580793..3581371 + 579 WP_003114949.1 HD domain-containing protein Toxin
HB733_RS16590 3581479..3582666 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB733_RS16595 3582656..3584827 - 2172 WP_023102113.1 type I secretion system permease/ATPase -
HB733_RS16600 3584817..3586094 - 1278 WP_003160086.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152575 WP_003114949.1 NZ_CP050330:3580793-3581371 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152575 NZ_CP066310:1730750-1730932 [Azotobacter chroococcum]
GTGAATAGCCGTGAAGTAATAGGCCTCATCGAGGCGGACGGCTGGTATCTGGTGCGCGTGAATGGCAGTCATCACCACTT
CAAGCACCCGACCAAGCCTGGGCTGGTCACCATCCCGCACCCGAAGAAGGATCTGCTGGCCAAGACAGTCGGCAGCATCT
TGAAACAGGCCGGACTCAAATAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152575 WP_003088112.1 NZ_CP050330:3580150-3580704 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152575 NZ_CP066310:1730962-1731369 [Azotobacter chroococcum]
ATGCTTTATCCAATTGCAATCTCACCCGGCGACGAGCAGCACGCCTGGGGCGTCGAAGTGCCGGACATCCTCGGCTGTTT
CTCTGCGGGCGATAACCTGGACGATGCAATGGCGATGGCTCGCGAGGCCATCGAGGGGCATCTGGAACTGTTGGCCGAGG
AGGGCGCGCAGATCCCCGAGGCGAGCAGTGTGACCACGCATGCGAGCAATCCGGACTATGCCGGTTGCACCTGGGCGGTG
GTAGACATCGATGTGACCCGGTACATGGGCAAGGCAGAGAAACTGAACATCACGCTGCCGGGGCACTTGCTGGCCCGGAT
CGATGCCTATGTGAAGGCCCATCCGGAGCAGAAGAGCCGCTCCGGCTTCCTGGCTGCTGCAGCATTGAAGGCATTGCAGC
ACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References