Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3524690..3525911 Replicon chromosome
Accession NZ_CP050329
Organism Pseudomonas aeruginosa strain DVT417

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB734_RS16225 Protein ID WP_003114949.1
Coordinates 3525333..3525911 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB734_RS16220 Protein ID WP_003088112.1
Coordinates 3524690..3525244 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB734_RS16195 3520258..3520809 + 552 WP_003102727.1 XRE family transcriptional regulator -
HB734_RS16200 3520806..3521204 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HB734_RS16205 3521217..3521540 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HB734_RS16210 3521871..3522332 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB734_RS16215 3522337..3524532 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB734_RS16220 3524690..3525244 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HB734_RS16225 3525333..3525911 + 579 WP_003114949.1 HD domain-containing protein Toxin
HB734_RS16230 3526019..3527206 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB734_RS16235 3527196..3529367 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
HB734_RS16240 3529357..3530634 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152569 WP_003114949.1 NZ_CP050329:3525333-3525911 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152569 NZ_CP066307:42552-42989 [Pseudomonas putida]
ATGAGCAAAAAGACGTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGCCCCGACGCGGTGCTGGCCAA
GCTGGAACAGGCAGTCACTAATCAGCACCGGATTGTCGTTTCGGCCATCACCTACTCCGAAATGCGTTTCGGGGCCGCCA
ACCCCAAGGCATCGCCCAAGGTTGCAGCGATGGTCGATGCCTTCATCCAGCGCCTGGACGCCATCCTGTCCTGGGACGCC
GCCGCCGTAGATCAAACAACGCAGATCCGCACCGCCCTCGCCCGCCTGGGTACGCCCATTGGCAACAACGATGCAGCGAT
AGCCGGCCATGCCCTGGCCGCTGGGTGTGTTCTGGTCACGAACAACACTCGCGAATTTGCTCGCGTTCCTGGCCTAGTCC
TTGAGGACTGGACCCAACCCGCCATTACCAAGAGTTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152569 WP_003088112.1 NZ_CP050329:3524690-3525244 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152569 NZ_CP066307:42319-42555 [Pseudomonas putida]
ATGCGTACCGTTTCCATTTTCATGAACAGCCGAAACCAGGCGATCCGCATCCCTCGGGATATGGAGTACCAGGGCGTTTC
CGAGCTGGAGATTATCCGCGACGGCGAAACGCTGATCCTGCGCCCTGTGCGCCCCTCCTGGGCATCGTTGCGCGACGTGG
CGGCCGCAGATCCTGACTTTCTGACCGAGCGAAAGGATGTGATCGAGGAAGACCGTTTCCTGGGTGACTTCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References