152567

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148960..149465 Replicon chromosome
Accession NZ_CP050329
Organism Pseudomonas aeruginosa strain DVT417

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HB734_RS00670 Protein ID WP_003083773.1
Coordinates 148960..149241 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HB734_RS00675 Protein ID WP_003112628.1
Coordinates 149238..149465 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB734_RS00645 144211..145560 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HB734_RS00650 145609..146295 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB734_RS00655 146396..147130 + 735 WP_003115036.1 GntR family transcriptional regulator -
HB734_RS00660 147334..147720 + 387 WP_014602345.1 aegerolysin family protein -
HB734_RS00665 147752..148660 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB734_RS00670 148960..149241 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HB734_RS00675 149238..149465 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HB734_RS00680 149641..150261 - 621 WP_003101226.1 hypothetical protein -
HB734_RS00685 150362..150862 + 501 WP_003112629.1 LEA type 2 family protein -
HB734_RS00690 150935..151276 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB734_RS00695 151358..152785 - 1428 WP_003083784.1 GABA permease -
HB734_RS00700 152954..154447 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T152567 WP_003083773.1 NZ_CP050329:c149241-148960 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152567 NZ_CP066306:5109893-5110303 [Pseudomonas putida]
ATGCTCAAGTACATGCTCGATACGAATATCTGCATCTTCACGATCAAGAACAAACCCCAGGTAGTTCGTGAAGCGTTCAA
CCGCCACCATGGTCAGCTGGCAATCAGCACCGTCACACTGATGGAGCTTGTTTACGGTGCAGAGAAATCGGCCGCTCCTG
CACGAAATCTCTCGATTGTGGAGGGTTTCGTAGCGCGTCTTGAAGTACTCGACTATGACAGCCATGCAGCAGAACACAGC
GGGCAGCTTCGCTCAGAACTGGCAAAGGCCGGTACGCCCATCGGTCCTTTCGATCAGTTGATTGCCGGGCATGCCCGCGC
GCGGGGGCTTACCTTGGTAACAAACAACCTGCGAGAGTTCATGCGCGTTCCGGGGTTGCGGGTTGAGGATTGGCTGGCCA
TGCCAGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT152567 WP_003112628.1 NZ_CP050329:c149465-149238 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT152567 NZ_CP066306:5109663-5109893 [Pseudomonas putida]
ATGGAGCAAGGTGCTGTCTTCAAAAGCAATCGTAGCCAGGCCATCCGCTTGCCGAAATCTGTCGCATTTCCCGAAGAGGT
GACCCGCGTGGACATTGTTGCAGTGGGTCGAACCCGCATCATCACTCCCGCTGGTGAATCATGGGATAGCTGGTTTGACG
GCGAAGATGCGAGCCCGGACTTCATGGCCAGCCGCGACCAACCTGCCGACCAGGAACGTGAAGGGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References