152564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2632839..2634060 Replicon chromosome
Accession NZ_CP050328
Organism Pseudomonas aeruginosa strain DVT419

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB736_RS12440 Protein ID WP_003114949.1
Coordinates 2632839..2633417 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB736_RS12445 Protein ID WP_019371885.1
Coordinates 2633506..2634060 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB736_RS12425 2628116..2629393 + 1278 WP_003102743.1 TolC family protein -
HB736_RS12430 2629383..2631554 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
HB736_RS12435 2631544..2632731 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB736_RS12440 2632839..2633417 - 579 WP_003114949.1 HD domain-containing protein Toxin
HB736_RS12445 2633506..2634060 - 555 WP_019371885.1 helix-turn-helix domain-containing protein Antitoxin
HB736_RS12450 2634218..2636413 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB736_RS12455 2636418..2636879 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB736_RS12460 2637210..2637533 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HB736_RS12465 2637546..2637944 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HB736_RS12470 2637941..2638492 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152564 WP_003114949.1 NZ_CP050328:c2633417-2632839 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152564 NZ_CP066303:c1644835-1644473 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20440.60 Da        Isoelectric Point: 8.1590

>AT152564 WP_019371885.1 NZ_CP050328:c2634060-2633506 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLDELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152564 NZ_CP066303:c1645002-1644832 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References