Detailed information of TA system TA152560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142143..142648
• Replicon: chromosome
• Accession: NZ_CP050328
• Organism: Pseudomonas aeruginosa strain DVT419

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: HB736_RS00655
• Protein ID: WP_003083773.1
• Coordinates: 142143..142424 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HB736_RS00660
• Protein ID: WP_003083775.1
• Coordinates: 142421..142648 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB736_RS00630	137394..138743	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
HB736_RS00635	138792..139478	+	687	WP_003083762.1	FadR family transcriptional regulator	-
HB736_RS00640	139579..140313	+	735	WP_003117208.1	GntR family transcriptional regulator	-
HB736_RS00645	140517..140903	+	387	WP_003083767.1	aegerolysin family protein	-
HB736_RS00650	140935..141843	-	909	WP_003083769.1	LysR family transcriptional regulator	-
HB736_RS00655	142143..142424	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
HB736_RS00660	142421..142648	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HB736_RS00665	142823..143443	-	621	WP_003101226.1	hypothetical protein	-
HB736_RS00670	143544..144044	+	501	WP_003162763.1	LEA type 2 family protein	-
HB736_RS00675	144117..144458	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
HB736_RS00680	144540..145967	-	1428	WP_003083784.1	GABA permease	-
HB736_RS00685	146136..147629	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T152560 WP_003083773.1 NZ_CP050328:c142424-142143 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T152560 NZ_CP066273:409735-410154 [Agrobacterium tumefaciens]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT152560 WP_003083775.1 NZ_CP050328:c142648-142421 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT152560 NZ_CP066273:409484-409738 [Agrobacterium tumefaciens]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9