Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2459139..2460360 Replicon chromosome
Accession NZ_CP050327
Organism Pseudomonas aeruginosa strain DVT421

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB737_RS11555 Protein ID WP_012614272.1
Coordinates 2459139..2459717 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB737_RS11560 Protein ID WP_003088112.1
Coordinates 2459806..2460360 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB737_RS11540 2454487..2455764 + 1278 WP_003102743.1 TolC family protein -
HB737_RS11545 2455754..2457925 + 2172 WP_023110129.1 type I secretion system permease/ATPase -
HB737_RS11550 2457915..2459102 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB737_RS11555 2459139..2459717 - 579 WP_012614272.1 HD domain-containing protein Toxin
HB737_RS11560 2459806..2460360 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HB737_RS11565 2460518..2462713 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB737_RS11570 2462718..2463179 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB737_RS11575 2463510..2463833 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HB737_RS11580 2463846..2464244 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HB737_RS11585 2464241..2464792 - 552 WP_004343115.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21899.72 Da        Isoelectric Point: 5.3655

>T152558 WP_012614272.1 NZ_CP050327:c2459717-2459139 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLASLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T152558 NZ_CP066273:c211912-211511 [Agrobacterium tumefaciens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TT

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152558 WP_003088112.1 NZ_CP050327:c2460360-2459806 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152558 NZ_CP066273:c212142-211912 [Agrobacterium tumefaciens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References