Detailed information of TA system TA152555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 141981..142486
• Replicon: chromosome
• Accession: NZ_CP050327
• Organism: Pseudomonas aeruginosa strain DVT421

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: HB737_RS00640
• Protein ID: WP_003083773.1
• Coordinates: 141981..142262 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HB737_RS00645
• Protein ID: WP_003083775.1
• Coordinates: 142259..142486 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB737_RS00615	137232..138581	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
HB737_RS00620	138630..139316	+	687	WP_003083762.1	FadR family transcriptional regulator	-
HB737_RS00625	139417..140151	+	735	Protein_124	GntR family transcriptional regulator	-
HB737_RS00630	140355..140741	+	387	WP_014602345.1	aegerolysin family protein	-
HB737_RS00635	140773..141681	-	909	WP_012613448.1	LysR family transcriptional regulator	-
HB737_RS00640	141981..142262	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
HB737_RS00645	142259..142486	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HB737_RS00650	142662..143282	-	621	WP_003101226.1	hypothetical protein	-
HB737_RS00655	143383..143883	+	501	WP_003101228.1	LEA type 2 family protein	-
HB737_RS00660	143956..144297	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
HB737_RS00665	144379..145806	-	1428	WP_003083784.1	GABA permease	-
HB737_RS00670	145975..147468	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T152555 WP_003083773.1 NZ_CP050327:c142262-141981 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T152555 NZ_CP066271:89930-90205 [Pseudomonas tremae]
ATGGAATTGAAGTGGACAAGCAAGGCGCTTTCCGACATTACCCGGCTATACGAGTTTCTGGCCTCTGTGAATCAACCTGC
TGCCGCACGAGCAGTGCAGCAACTCACCACCGCACCTACCACGCTGCTGACCAATCCGCGCATTGGAGAACGCCTGGAGG
AATTCGAGCCAAGGGACGTACGCCGAATTCAGATCGGCCAATACGAGATGCGTTACGAGATAGCGGATTCCACTATCTAC
CTGCTGCGCCTGTGGCACACCCGCGAAGACCGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT152555 WP_003083775.1 NZ_CP050327:c142486-142259 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT152555 NZ_CP066271:89658-89930 [Pseudomonas tremae]
ATGGCAACCACCGCCAAAACCCGATCCGTCACAGCTCACGTTCCGGTGCAACTGGCGGAAAAAGTCGATTTGATGGCTGA
GCGTCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAAGCTCTGTCCGCTTGGATAGACCAAGAAGAAGAGCGTAGTCGCC
TGACCCGTGAGGCTTTGGCTGATGTTGACGCTGGACGCGTTATTGACCACCAAGCCGTCCAGGCCTGGGCTGACAGTCTC
AGCACCGACACTCCGTTGCCGGTGCCGCGCTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9