152551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4818062..4818670 Replicon chromosome
Accession NZ_CP050325
Organism Pseudomonas aeruginosa strain DVT425

Toxin (Protein)


Gene name PfiT Uniprot ID A0A3S4N9Q9
Locus tag HB740_RS22385 Protein ID WP_031672658.1
Coordinates 4818062..4818409 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HB740_RS22390 Protein ID WP_003114155.1
Coordinates 4818419..4818670 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB740_RS22355 4813421..4813693 + 273 WP_021264275.1 cysteine-rich CWC family protein -
HB740_RS22360 4813693..4814385 + 693 WP_022579823.1 16S rRNA pseudouridine(516) synthase -
HB740_RS22365 4814521..4815564 + 1044 WP_003110811.1 L,D-transpeptidase -
HB740_RS22370 4815644..4816381 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
HB740_RS22375 4816833..4817735 + 903 WP_033944889.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
HB740_RS22385 4818062..4818409 - 348 WP_031672658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB740_RS22390 4818419..4818670 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HB740_RS22395 4818884..4819867 - 984 WP_031672657.1 tyrosine-type recombinase/integrase -
HB740_RS22400 4819867..4821159 - 1293 WP_003123045.1 hypothetical protein -
HB740_RS22405 4821418..4822680 - 1263 WP_033940348.1 hypothetical protein -
HB740_RS22410 4822682..4823032 - 351 WP_003159569.1 DUF2523 domain-containing protein -
HB740_RS22415 4823042..4823650 - 609 WP_003163344.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4818062..4841103 23041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12898.69 Da        Isoelectric Point: 4.5143

>T152551 WP_031672658.1 NZ_CP050325:c4818409-4818062 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGAQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T152551 NZ_CP066267:5847958-5848308 [Pseudomonas tremae]
ATGAATACGTTTGCACTGCGCTTTACCGATGTTGCCCAGCAAAGCCTTGAGGATCAGGTTGAACACCTGGCTGTCCATCA
GGGATTCTCATCAGCTGCTCAACGCATAGATTCCCTTATCGATGCCATCCAGGACAAGCTCCTGTCCACCCCTTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGTGTACTGCACTATCGTGAGTTGAACACTGACGGATACCGGATCTTTTAC
GAGGTGATGGATTCAGAAGGTATTACAGTCATCGTCGTATTGCTCGTATTGGGTGGTAAACAGAGTGTTGAACAGGCTTT
GATCCGCTACTGTCTGCTACAGCCTATTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT152551 WP_003114155.1 NZ_CP050325:c4818670-4818419 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT152551 NZ_CP066267:5847697-5847945 [Pseudomonas tremae]
ATGCGAGTTGAAACAATTAGCTATCTGAAACGCAACGCAGCCGACCTGCCTCTCGATGAGCCATTGGTCGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCTGATCGTAAGCGCCGCGATGAGTCAATCGCCTTGGTGAAGCTCCTGG
CAATCAGCTCCCGCGAGTACGCCCAAGGCAAGCACTGTTCCACTGACGAACTCAAAGCCCGATTGAGCAGGAGGTTTATC
CAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4N9Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References