Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3116800..3118021 Replicon chromosome
Accession NZ_CP050325
Organism Pseudomonas aeruginosa strain DVT425

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB740_RS14275 Protein ID WP_003160088.1
Coordinates 3117443..3118021 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB740_RS14270 Protein ID WP_003088112.1
Coordinates 3116800..3117354 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB740_RS14245 3112368..3112919 + 552 WP_003102727.1 XRE family transcriptional regulator -
HB740_RS14250 3112916..3113314 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HB740_RS14255 3113327..3113650 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HB740_RS14260 3113981..3114442 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HB740_RS14265 3114447..3116642 + 2196 WP_174707867.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HB740_RS14270 3116800..3117354 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HB740_RS14275 3117443..3118021 + 579 WP_003160088.1 HD domain-containing protein Toxin
HB740_RS14280 3118130..3119317 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HB740_RS14285 3119307..3121478 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
HB740_RS14290 3121468..3122745 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T152548 WP_003160088.1 NZ_CP050325:3117443-3118021 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T152548 NZ_CP066265:58966-59184 [Pseudomonas syringae]
GTGATTGTGAGTTTTAGATGCGTGCATACGAGCGACCTTTTCGAGCACGGCAAAACCCGGTTATGGGCTTCGATAAAATC
AGTTGCCGAGCGCAAACTTGCGATGCTTGATGGGGATCGCTTTGGCCAATACAGCATCCGCATAAACGCTCAATTCAGGA
TCTGCTTCATTTGGGGCGTTAATGGTCCCGAAAACGTTGAAATCATCGATTACCATTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152548 WP_003088112.1 NZ_CP050325:3116800-3117354 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152548 NZ_CP066265:59194-59499 [Pseudomonas syringae]
ATGAACAAAAACGGAATGCGCCCCGTGCATCCAGGTGAAGTCCTTAGAGAGGAATACCTGGAGCCCATGCGACTGACCGC
TGCGGCGCTGGCTCGGGCATTAGGTGTTTCAACGCCGACGGTGAATGACATTGTGCTCCAGCGCCGCGGAGTAAGTGCTG
ATGTGGCGCTGCGTCTGGCCGCATGCCTGGAGACGAGTCCCGAGTTCTGGCTTAACTTGCAGCTTGCCTACGATCTGCGC
AAGGCAGAGATCGAGAAGGGCGCGCAGATTCGTGAGCAGGTCAGGAGTCTGGCCCGCTGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References