Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142105..142610 Replicon chromosome
Accession NZ_CP050325
Organism Pseudomonas aeruginosa strain DVT425

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HB740_RS00650 Protein ID WP_003083773.1
Coordinates 142105..142386 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HB740_RS00655 Protein ID WP_003112628.1
Coordinates 142383..142610 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB740_RS00625 137356..138705 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HB740_RS00630 138754..139440 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB740_RS00635 139541..140275 + 735 WP_003117208.1 GntR family transcriptional regulator -
HB740_RS00640 140479..140865 + 387 WP_003083767.1 aegerolysin family protein -
HB740_RS00645 140897..141805 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB740_RS00650 142105..142386 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HB740_RS00655 142383..142610 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HB740_RS00660 142785..143405 - 621 WP_003101226.1 hypothetical protein -
HB740_RS00665 143506..144006 + 501 WP_003112629.1 LEA type 2 family protein -
HB740_RS00670 144079..144420 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB740_RS00675 144502..145929 - 1428 WP_003083784.1 GABA permease -
HB740_RS00680 146098..147591 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T152546 WP_003083773.1 NZ_CP050325:c142386-142105 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152546 NZ_CP066258:c10141-9827 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT152546 WP_003112628.1 NZ_CP050325:c142610-142383 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT152546 NZ_CP066258:c10407-10129 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References