Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141186..141691 Replicon chromosome
Accession NZ_CP050324
Organism Pseudomonas aeruginosa strain DVT427

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag HB742_RS00645 Protein ID WP_003121619.1
Coordinates 141186..141467 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HB742_RS00650 Protein ID WP_003112628.1
Coordinates 141464..141691 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB742_RS00620 136437..137786 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HB742_RS00625 137835..138521 + 687 WP_033877486.1 FadR family transcriptional regulator -
HB742_RS00630 138622..139356 + 735 WP_004346926.1 GntR family transcriptional regulator -
HB742_RS00635 139560..139946 + 387 WP_014602345.1 aegerolysin family protein -
HB742_RS00640 139978..140886 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB742_RS00645 141186..141467 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
HB742_RS00650 141464..141691 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HB742_RS00655 141867..142487 - 621 WP_023088714.1 hypothetical protein -
HB742_RS00660 142588..143088 + 501 WP_003101228.1 LEA type 2 family protein -
HB742_RS00665 143161..143502 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB742_RS00670 143584..145011 - 1428 WP_003083784.1 GABA permease -
HB742_RS00675 145180..146673 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T152539 WP_003121619.1 NZ_CP050324:c141467-141186 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152539 NZ_CP066254:c5324669-5324286 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT152539 WP_003112628.1 NZ_CP050324:c141691-141464 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT152539 NZ_CP066254:c5324911-5324669 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References