Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143637..144142 Replicon chromosome
Accession NZ_CP050323
Organism Pseudomonas aeruginosa strain DVT429

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HB744_RS00670 Protein ID WP_003083773.1
Coordinates 143637..143918 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HB744_RS00675 Protein ID WP_003083775.1
Coordinates 143915..144142 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB744_RS00645 138888..140237 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HB744_RS00650 140286..140972 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB744_RS00655 141073..141807 + 735 WP_003117208.1 GntR family transcriptional regulator -
HB744_RS00660 142011..142397 + 387 WP_014602345.1 aegerolysin family protein -
HB744_RS00665 142429..143337 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB744_RS00670 143637..143918 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HB744_RS00675 143915..144142 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HB744_RS00680 144318..144938 - 621 WP_003101226.1 hypothetical protein -
HB744_RS00685 145039..145539 + 501 WP_003101228.1 LEA type 2 family protein -
HB744_RS00690 145612..145953 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB744_RS00695 146035..147462 - 1428 WP_003083784.1 GABA permease -
HB744_RS00700 147631..149124 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T152533 WP_003083773.1 NZ_CP050323:c143918-143637 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152533 NZ_CP066254:2013773-2013875 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT152533 WP_003083775.1 NZ_CP050323:c144142-143915 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT152533 NZ_CP066254:c2013882-2013737 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References