Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1400487..1401157 Replicon chromosome
Accession NZ_CP050322
Organism Pseudomonas aeruginosa strain DVT729

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB747_RS06370 Protein ID WP_023114647.1
Coordinates 1400738..1401157 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB747_RS06365 Protein ID WP_023114648.1
Coordinates 1400487..1400741 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB747_RS06345 1396029..1397029 - 1001 Protein_1252 LuxR family transcriptional regulator -
HB747_RS06350 1397114..1397338 + 225 WP_023114650.1 AlpA family phage regulatory protein -
HB747_RS06355 1397341..1398234 + 894 WP_031637438.1 helicase RepA family protein -
HB747_RS06360 1398215..1399192 + 978 WP_031637437.1 plasmid replication -
HB747_RS06365 1400487..1400741 + 255 WP_023114648.1 Arc family DNA-binding protein Antitoxin
HB747_RS06370 1400738..1401157 + 420 WP_023114647.1 type II toxin-antitoxin system VapC family toxin Toxin
HB747_RS06375 1401313..1402083 + 771 WP_174707167.1 P-type conjugative transfer protein TrbJ -
HB747_RS06380 1402097..1402255 + 159 WP_023114645.1 hypothetical protein -
HB747_RS06385 1402257..1403728 + 1472 Protein_1260 P-type conjugative transfer protein TrbL -
HB747_RS06390 1403797..1404039 + 243 WP_023114643.1 type I toxin-antitoxin system ptaRNA1 family toxin -
HB747_RS06395 1404051..1404335 + 285 WP_023114642.1 hypothetical protein -
HB747_RS06400 1404338..1404706 + 369 WP_023114641.1 conjugal transfer transcriptional regulator TraJ -
HB747_RS06405 1404745..1405203 - 459 WP_023114640.1 helix-turn-helix domain-containing protein -
HB747_RS06410 1405488..1405604 + 117 Protein_1265 resolvase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1394425..1417051 22626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14925.16 Da        Isoelectric Point: 5.1890

>T152527 WP_023114647.1 NZ_CP050322:1400738-1401157 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T152527 NZ_CP066252:53004-53318 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.87 Da        Isoelectric Point: 6.4760

>AT152527 WP_023114648.1 NZ_CP050322:1400487-1400741 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT152527 NZ_CP066252:52738-53016 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References