Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148114..148619 Replicon chromosome
Accession NZ_CP050322
Organism Pseudomonas aeruginosa strain DVT729

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HB747_RS00680 Protein ID WP_023114790.1
Coordinates 148114..148395 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HB747_RS00685 Protein ID WP_003083775.1
Coordinates 148392..148619 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB747_RS00655 143365..144714 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HB747_RS00660 144763..145449 + 687 WP_003083762.1 FadR family transcriptional regulator -
HB747_RS00665 145550..146284 + 735 WP_003117208.1 GntR family transcriptional regulator -
HB747_RS00670 146488..146874 + 387 WP_014602345.1 aegerolysin family protein -
HB747_RS00675 146906..147814 - 909 WP_003083769.1 LysR family transcriptional regulator -
HB747_RS00680 148114..148395 - 282 WP_023114790.1 type II toxin-antitoxin system toxin ParE Toxin
HB747_RS00685 148392..148619 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HB747_RS00690 148795..149415 - 621 WP_003101226.1 hypothetical protein -
HB747_RS00695 149516..150016 + 501 WP_003101228.1 LEA type 2 family protein -
HB747_RS00700 150089..150430 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HB747_RS00705 150512..151939 - 1428 WP_003083784.1 GABA permease -
HB747_RS00710 152108..153601 - 1494 WP_174707058.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10464.21 Da        Isoelectric Point: 10.0014

>T152526 WP_023114790.1 NZ_CP050322:c148395-148114 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Download         Length: 282 bp

>T152526 NZ_CP066251:121084-121233 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT152526 WP_003083775.1 NZ_CP050322:c148619-148392 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT152526 NZ_CP066251:c121039-120980 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References