Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1554044..1554584 Replicon chromosome
Accession NZ_CP050316
Organism Avibacterium paragallinarum strain ESV-135

Toxin (Protein)


Gene name relE Uniprot ID A0A3G8VZS8
Locus tag HBL79_RS07280 Protein ID WP_035688134.1
Coordinates 1554044..1554334 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G8W1I3
Locus tag HBL79_RS07285 Protein ID WP_035688131.1
Coordinates 1554324..1554584 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBL79_RS07240 1550476..1550817 - 342 WP_035688146.1 hypothetical protein -
HBL79_RS07245 1550817..1551041 - 225 WP_035688166.1 hypothetical protein -
HBL79_RS07250 1551046..1551315 - 270 WP_035688144.1 hypothetical protein -
HBL79_RS07255 1551308..1551538 - 231 WP_035688141.1 hypothetical protein -
HBL79_RS07260 1551531..1552103 - 573 WP_051128102.1 ash family protein -
HBL79_RS07265 1552207..1552512 - 306 WP_035688139.1 hypothetical protein -
HBL79_RS07270 1552523..1552738 - 216 WP_035688136.1 helix-turn-helix domain-containing protein -
HBL79_RS07275 1552902..1554002 - 1101 WP_051128101.1 hypothetical protein -
HBL79_RS07280 1554044..1554334 - 291 WP_035688134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBL79_RS07285 1554324..1554584 - 261 WP_035688131.1 stability protein StbD Antitoxin
HBL79_RS07290 1554723..1555688 - 966 WP_035688129.1 P2 family phage major capsid protein -
HBL79_RS07295 1555700..1556377 - 678 WP_035688128.1 hypothetical protein -
HBL79_RS07300 1556381..1556587 - 207 WP_035688126.1 AlpA family phage regulatory protein -
HBL79_RS07305 1556867..1557016 + 150 WP_156127747.1 hypothetical protein -
HBL79_RS07310 1557247..1558458 - 1212 WP_035688123.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11399.31 Da        Isoelectric Point: 10.6318

>T152525 WP_035688134.1 NZ_CP050316:c1554334-1554044 [Avibacterium paragallinarum]
MTYKLSFDKRALKEWHKLGDTLRQQFKAKLIERLENPHVLSDKLHGYQTLYKIKLRSAGYRLVYDVNDNEIRVIVLSVGK
REHLQAYKKALSRKAQ

Download         Length: 291 bp

>T152525 NZ_CP066251:23465-23623 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9550.98 Da        Isoelectric Point: 4.1813

>AT152525 WP_035688131.1 NZ_CP050316:c1554584-1554324 [Avibacterium paragallinarum]
MAIQQILTRHTASISDLKKNPMGIVSEGTEQEGAIAILNRNEPVFYCVNPCLFAVIQEILEDKELGELATQRLATLDPVE
VRLDDL

Download         Length: 261 bp

>AT152525 NZ_CP066251:23354-23419 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8VZS8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8W1I3

References