Detailed information of TA system TA152521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 565914..566501
• Replicon: chromosome
• Accession: NZ_CP050316
• Organism: Avibacterium paragallinarum strain ESV-135

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBL79_RS02875
• Protein ID: WP_103846679.1
• Coordinates: 566238..566501 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: HBL79_RS02870
• Protein ID: WP_035686016.1
• Coordinates: 565914..566204 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBL79_RS02845	561121..562233	+	1113	WP_035685801.1	porin	-
HBL79_RS02850	562506..563573	+	1068	WP_046097416.1	porin	-
HBL79_RS02855	563796..563978	+	183	WP_124994837.1	hypothetical protein	-
HBL79_RS02860	563923..564876	+	954	WP_124994836.1	porin	-
HBL79_RS02865	564997..565722	-	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
HBL79_RS02870	565914..566204	+	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HBL79_RS02875	566238..566501	+	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HBL79_RS02880	566590..568368	+	1779	WP_035685792.1	aspartate--tRNA ligase	-
HBL79_RS02885	568494..568937	+	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
HBL79_RS02890	569391..570131	+	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
HBL79_RS02895	570207..570767	+	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
HBL79_RS02900	570855..571469	+	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T152521 WP_103846679.1 NZ_CP050316:566238-566501 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T152521 NZ_CP066250:21353-21796 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT152521 WP_035686016.1 NZ_CP050316:565914-566204 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT152521 NZ_CP066250:21126-21356 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1