Detailed information of TA system TA152516

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2684137..2684659
• Replicon: chromosome
• Accession: NZ_CP050313
• Organism: Shewanella aestuarii strain PN3F2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBH39_RS11790
• Protein ID: WP_167678495.1
• Coordinates: 2684372..2684659 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HBH39_RS11785
• Protein ID: WP_208764217.1
• Coordinates: 2684137..2684385 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBH39_RS11765	2679180..2680184	-	1005	WP_167678487.1	SEC-C domain-containing protein	-
HBH39_RS11770	2681144..2683204	-	2061	WP_167678489.1	CHASE3 domain-containing protein	-
HBH39_RS11775	2683392..2683484	-	93	Protein_2271	transposase	-
HBH39_RS11780	2683739..2684038	+	300	WP_167678491.1	transposase	-
HBH39_RS11785	2684137..2684385	+	249	WP_208764217.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HBH39_RS11790	2684372..2684659	+	288	WP_167678495.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HBH39_RS11795	2684646..2684840	-	195	WP_167674520.1	hypothetical protein	-
HBH39_RS11800	2685070..2685543	+	474	WP_167678497.1	hypothetical protein	-
HBH39_RS11805	2685701..2687299	+	1599	WP_167678499.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-76)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11372.32 Da
• Isoelectric Point: 10.6462

>T152516 WP_167678495.1 NZ_CP050313:2684372-2684659 [Shewanella aestuarii]
MTTYKLVFKRDAEKEWRKLDSPIREQFKKKLLERLENPRVESARLSGMEDCYKIKLRSAGYRLVYQVRDNELVISVVAVG
KRERNHVYKTAVKRI

Nucleotide

• Length: 288 bp

>T152516 NZ_CP066249:4190151-4190369 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9261.54 Da
• Isoelectric Point: 3.9437

>AT152516 WP_208764217.1 NZ_CP050313:2684137-2684385 [Shewanella aestuarii]
IIRPILADNTTSISELKKNPMAVVEQADGFPVAVLNRNKPEFYCVPADAYEAMLDKLEDIELTQLVKERLEQDEVEVSLD
DL

Nucleotide

• Length: 249 bp

>AT152516 NZ_CP066249:4189750-4190124 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG