Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4478162..4478769 Replicon chromosome
Accession NZ_CP050311
Organism Enterobacter hormaechei strain CM18-216

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HBK83_RS21060 Protein ID WP_017382585.1
Coordinates 4478584..4478769 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HBK83_RS21055 Protein ID WP_017382586.1
Coordinates 4478162..4478569 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBK83_RS21025 4474008..4474661 + 654 WP_017382590.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
HBK83_RS21030 4474664..4475524 + 861 WP_017382589.1 L-ribulose-5-phosphate 3-epimerase -
HBK83_RS21035 4475518..4476213 + 696 WP_017382588.1 L-ribulose-5-phosphate 4-epimerase -
HBK83_RS21040 4476214..4476501 - 288 Protein_4105 helix-turn-helix domain-containing protein -
HBK83_RS21045 4476508..4476876 + 369 Protein_4106 glycoside hydrolase family 127 protein -
HBK83_RS21050 4477083..4478158 + 1076 Protein_4107 type I restriction enzyme HsdR N-terminal domain-containing protein -
HBK83_RS21055 4478162..4478569 - 408 WP_017382586.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HBK83_RS21060 4478584..4478769 - 186 WP_017382585.1 type II toxin-antitoxin system HicA family toxin Toxin
HBK83_RS21065 4479019..4480557 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
HBK83_RS21070 4480724..4481608 + 885 WP_163367574.1 ROK family protein -
HBK83_RS21075 4481612..4483450 - 1839 WP_017382583.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6794.98 Da        Isoelectric Point: 11.4624

>T152510 WP_017382585.1 NZ_CP050311:c4478769-4478584 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTTGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T152510 NZ_CP066249:328895-329263 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15171.94 Da        Isoelectric Point: 4.3197

>AT152510 WP_017382586.1 NZ_CP050311:c4478569-4478162 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEAFPLPGNVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Download         Length: 408 bp

>AT152510 NZ_CP066249:328677-328898 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References