Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2315840..2316579 Replicon chromosome
Accession NZ_CP050311
Organism Enterobacter hormaechei strain CM18-216

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag HBK83_RS10830 Protein ID WP_003857133.1
Coordinates 2316094..2316579 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag HBK83_RS10825 Protein ID WP_003857131.1
Coordinates 2315840..2316106 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBK83_RS10805 2311315..2312301 + 987 WP_017382341.1 DUF979 domain-containing protein -
HBK83_RS10810 2312311..2313306 + 996 WP_017382342.1 DUF2891 domain-containing protein -
HBK83_RS10815 2313329..2314717 - 1389 WP_017382343.1 MFS transporter -
HBK83_RS10820 2314847..2315776 + 930 WP_026080525.1 LysR family transcriptional regulator -
HBK83_RS10825 2315840..2316106 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
HBK83_RS10830 2316094..2316579 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
HBK83_RS10835 2316630..2317199 - 570 WP_017382346.1 hypothetical protein -
HBK83_RS10840 2317215..2318180 - 966 WP_045338503.1 hypothetical protein -
HBK83_RS10845 2318435..2318763 + 329 Protein_2112 helix-turn-helix domain-containing protein -
HBK83_RS10850 2319192..2319638 + 447 WP_014069654.1 DUF3290 domain-containing protein -
HBK83_RS10855 2319648..2320283 + 636 WP_015570517.1 DUF421 domain-containing protein -
HBK83_RS10860 2320467..2321081 - 615 WP_080337195.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T152508 WP_003857133.1 NZ_CP050311:2316094-2316579 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T152508 NZ_CP066240:c5375-5088 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT152508 WP_003857131.1 NZ_CP050311:2315840-2316106 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT152508 NZ_CP066240:c5101-4787 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References