Detailed information of TA system TA152501

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1121368..1122151
• Replicon: chromosome
• Accession: NZ_CP050311
• Organism: Enterobacter hormaechei strain CM18-216

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A4R0G0V7
• Locus tag: HBK83_RS05285
• Protein ID: WP_004136885.1
• Coordinates: 1121368..1121742 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HBK83_RS05290
• Protein ID: WP_087528994.1
• Coordinates: 1121792..1122151 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBK83_RS05265	1116921..1118282	-	1362	WP_087528999.1	hypothetical protein	-
HBK83_RS05270	1118755..1119075	-	321	WP_047720740.1	hypothetical protein	-
HBK83_RS05275	1119840..1120829	+	990	WP_202768585.1	glycosyltransferase	-
HBK83_RS05280	1120968..1121288	+	321	WP_004136883.1	hypothetical protein	-
HBK83_RS05285	1121368..1121742	-	375	WP_004136885.1	TA system toxin CbtA family protein	Toxin
HBK83_RS05290	1121792..1122151	-	360	WP_087528994.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HBK83_RS05295	1122174..1122395	-	222	WP_064371656.1	DUF987 domain-containing protein	-
HBK83_RS05300	1122409..1122891	-	483	WP_202768587.1	DNA repair protein RadC	-
HBK83_RS05305	1123132..1123605	-	474	WP_202768589.1	antirestriction protein	-
HBK83_RS05310	1123684..1124505	-	822	WP_004136895.1	DUF945 domain-containing protein	-
HBK83_RS05315	1124612..1124824	-	213	WP_047720745.1	hypothetical protein	-
HBK83_RS05320	1124910..1125269	-	360	WP_004136901.1	hypothetical protein	-
HBK83_RS05325	1125324..1125788	-	465	WP_004136903.1	hypothetical protein	-
HBK83_RS05330	1126066..1126923	-	858	WP_025107340.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1105583..1144512	38929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (17-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13889.84 Da
• Isoelectric Point: 9.8173

>T152501 WP_004136885.1 NZ_CP050311:c1121742-1121368 [Enterobacter hormaechei]
MQIQSLSPQRAASSRLSSVESWRKLLEYLLKQHYGLMMNDTPFGDDSVIQKNIDAGISLCDAVNFIVEKYGLVRTDRHGF
SVTEQSPFIDSIDMLRARKATGLMTRKGYQTVTDITSGRSRGGK

Nucleotide

• Length: 375 bp

>T152501 NZ_CP066233:c4467-4108 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13334.46 Da
• Isoelectric Point: 7.7515

>AT152501 WP_087528994.1 NZ_CP050311:c1122151-1121792 [Enterobacter hormaechei]
MQKATRVINHNIAEPWRGLRRNITPCFGARLVQEGNHLHYFADRASIAGTFNEADLRYLDQAFPVLMKQMELMLASSELT
PHIQRCITLHAKGLICEADTLGSCGYLFIVIYPTSAISA

Nucleotide

• Length: 360 bp

>AT152501 NZ_CP066233:c4108-3809 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA

Structures

Toxin

• AlphaFold DB: A0A4R0G0V7