Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 849710..850367 Replicon chromosome
Accession NZ_CP050311
Organism Enterobacter hormaechei strain CM18-216

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag HBK83_RS04045 Protein ID WP_017382887.1
Coordinates 849957..850367 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HBK83_RS04040 Protein ID WP_003863437.1
Coordinates 849710..849976 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBK83_RS04020 845116..846549 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
HBK83_RS04025 846666..847397 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
HBK83_RS04030 847664..848323 + 660 WP_017382889.1 hemolysin III family protein -
HBK83_RS04035 848435..849415 - 981 WP_017382888.1 tRNA-modifying protein YgfZ -
HBK83_RS04040 849710..849976 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HBK83_RS04045 849957..850367 + 411 WP_017382887.1 protein YgfX Toxin
HBK83_RS04050 850369..850890 - 522 WP_015571793.1 flavodoxin FldB -
HBK83_RS04055 850992..851888 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HBK83_RS04060 851917..852630 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HBK83_RS04065 852636..854369 + 1734 WP_163367460.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T152499 WP_017382887.1 NZ_CP050311:849957-850367 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T152499 NZ_CP066232:c2706706-2706524 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT152499 WP_003863437.1 NZ_CP050311:849710-849976 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT152499 NZ_CP066232:c2706431-2706027 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References