Detailed information of TA system TA152498

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 104649..105368
• Replicon: chromosome
• Accession: NZ_CP050311
• Organism: Enterobacter hormaechei strain CM18-216

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HBK83_RS00525
• Protein ID: WP_040117033.1
• Coordinates: 104649..104969 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HBK83_RS00530
• Protein ID: WP_032620726.1
• Coordinates: 105003..105368 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBK83_RS00485	99924..100367	+	444	WP_017383639.1	GNAT family N-acetyltransferase	-
HBK83_RS00490	100400..100921	-	522	WP_017383638.1	hypothetical protein	-
HBK83_RS00495	100984..101349	-	366	WP_023302859.1	DUF2778 domain-containing protein	-
HBK83_RS00500	101359..101844	-	486	WP_017383637.1	type VI secretion system tube protein Hcp	-
HBK83_RS00505	102107..103135	-	1029	WP_202768571.1	virulence RhuM family protein	-
HBK83_RS00510	103194..103535	-	342	WP_006812446.1	SymE family type I addiction module toxin	-
HBK83_RS00515	103672..103863	+	192	WP_032620729.1	toxin-antitoxin system HicB family antitoxin	-
HBK83_RS00520	103865..104446	-	582	WP_017383635.1	hypothetical protein	-
HBK83_RS00525	104649..104969	-	321	WP_040117033.1	TA system toxin CbtA family protein	Toxin
HBK83_RS00530	105003..105368	-	366	WP_032620726.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HBK83_RS00535	105400..105621	-	222	WP_032620724.1	DUF987 domain-containing protein	-
HBK83_RS00540	105630..106100	-	471	WP_040117034.1	DNA repair protein RadC	-
HBK83_RS00545	106170..106991	-	822	WP_032620720.1	DUF945 domain-containing protein	-
HBK83_RS00550	107684..108523	-	840	WP_049125417.1	hypothetical protein	-
HBK83_RS00555	108636..109070	-	435	WP_044488933.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	96045..131391	35346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12206.77 Da
• Isoelectric Point: 5.9558

>T152498 WP_040117033.1 NZ_CP050311:c104969-104649 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQYNLGLKRS

Nucleotide

• Length: 321 bp

>T152498 NZ_CP066231:c5256-4969 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13574.29 Da
• Isoelectric Point: 6.4673

>AT152498 WP_032620726.1 NZ_CP050311:c105368-105003 [Enterobacter hormaechei]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT152498 NZ_CP066231:c4982-4668 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA