Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3617151..3617710 Replicon chromosome
Accession NZ_CP050308
Organism Rhizobium lusitanum strain 629

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB780_RS31230 Protein ID WP_183692136.1
Coordinates 3617151..3617516 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB780_RS31235 Protein ID WP_047464553.1
Coordinates 3617513..3617710 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB780_RS31210 3612196..3613440 - 1245 WP_183692128.1 efflux RND transporter periplasmic adaptor subunit -
HB780_RS31215 3613867..3614655 - 789 WP_183692130.1 SDR family oxidoreductase -
HB780_RS31220 3614952..3616616 + 1665 WP_183692132.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
HB780_RS31225 3616622..3617149 + 528 WP_183692134.1 GNAT family N-acetyltransferase -
HB780_RS31230 3617151..3617516 - 366 WP_183692136.1 PIN domain-containing protein Toxin
HB780_RS31235 3617513..3617710 - 198 WP_047464553.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HB780_RS31240 3617814..3618716 - 903 WP_183692138.1 DMT family transporter -
HB780_RS31245 3618862..3619335 + 474 WP_183692140.1 Lrp/AsnC family transcriptional regulator -
HB780_RS31250 3619388..3620761 - 1374 WP_183692142.1 magnesium transporter -
HB780_RS31255 3621116..3622129 - 1014 WP_183692143.1 zinc-binding alcohol dehydrogenase family protein -
HB780_RS31260 3622233..3622637 + 405 WP_183692145.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-47)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13762.01 Da        Isoelectric Point: 8.4792

>T152497 WP_183692136.1 NZ_CP050308:c3617516-3617151 [Rhizobium lusitanum]
MILVDTSIWIDHFHSLDIRLQSLLEQKQVLVHPFVVGEISLGNLRQYDLVMRSLSRLYQIAKASDDDVLYFIRTNKLQGA
GIGYVDAHLAAAAMLTPGTYLWTRDKRLQRVAENLRIAAPL

Download         Length: 366 bp

>T152497 NZ_CP066230:c20163-19804 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7060.10 Da        Isoelectric Point: 5.0506

>AT152497 WP_047464553.1 NZ_CP050308:c3617710-3617513 [Rhizobium lusitanum]
MRTTVAIDDKLLADAREVTGLAETSAILREALKALVEREAARTLIRLGGSEPDITAPPRRQFGVE

Download         Length: 198 bp

>AT152497 NZ_CP066230:c19804-19505 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References