Detailed information of TA system TA152491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 233579..234156
• Replicon: plasmid p_1
• Accession: NZ_CP050303
• Organism: Phyllobacterium sp. 628

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HB779_RS23675
• Protein ID: WP_188346830.1
• Coordinates: 233821..234156 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HB779_RS23670
• Protein ID: WP_188346829.1
• Coordinates: 233579..233821 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB779_RS23650	229948..230406	-	459	WP_188346903.1	MarR family transcriptional regulator	-
HB779_RS23655	230534..231850	+	1317	WP_188346826.1	homogentisate 1,2-dioxygenase	-
HB779_RS23660	231847..232866	+	1020	WP_188346827.1	fumarylacetoacetate hydrolase family protein	-
HB779_RS23665	232870..233514	+	645	WP_188346828.1	maleylacetoacetate isomerase	-
HB779_RS23670	233579..233821	+	243	WP_188346829.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HB779_RS23675	233821..234156	+	336	WP_188346830.1	endoribonuclease MazF	Toxin
HB779_RS23680	234159..235271	-	1113	WP_188346831.1	4-hydroxyphenylpyruvate dioxygenase	-
HB779_RS23685	235392..235853	+	462	WP_188346832.1	Lrp/AsnC family transcriptional regulator	-
HB779_RS23690	235893..236231	-	339	WP_188346833.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HB779_RS23695	236218..236436	-	219	WP_188346834.1	type II toxin-antitoxin system PrlF family antitoxin	-
HB779_RS23700	236507..237223	-	717	WP_188346835.1	ligase-associated DNA damage response endonuclease PdeM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..611708	611708

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-105)

Antitoxin

• Antitoxin PemI-like (1-79)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12009.97 Da
• Isoelectric Point: 9.2069

>T152491 WP_188346830.1 NZ_CP050303:233821-234156 [Phyllobacterium sp. 628]
MAAYVPDAGDIVWLHFNPQAGHEQAGHRPAVVLSPTSYNGKTSLMLCCPMTTQIKGYPFEVLIAGERPGAVLADQIKSLD
WRVRRATFKGKISATELAEICSKAAALIGKR

Nucleotide

• Length: 336 bp

>T152491 NZ_CP066218:c3120303-3119725 [Mycolicibacterium sp. LJ126]
ATGCACCGGCTCGACCTCGTCGTCGGACCCAACGGTGCCGGCAAGTCCACCTTCGTCGCGTTCACCCTGGGCCCACTGCT
GCCCGGCAGCCCGTTCCTCAACGCCGACGAGATCGCGAAACAACGCTGGCCCACTGACGCCGAGCGGCACTCCTATCAGG
CCGCTCGGGTCGCCGCCGCCACGCGCACCGCGTTGATCGAGGCGGGCCGGTCCTTCATCGCCGAGACCGTCTTCTCCCAT
CCTTCCAAGCTCGACCTCGTCGACGAAGCACTCGCCCGCGATTACACCGTCGTCCTGCACGTCCTGCTGATCCCCGAGGA
TCTGGCGGTCGAACGCGTCAAACACCGGGTGCTCGCCGGAGGGCACAACGTCGCCGAAGAGAAGATCCGCGAACGTCACC
GCCGGCTCTGGGACCTCGTGGTGCGCGCAATCGGGTCCTGCGACAGCGCGACCGTCTACGACAACAGCGACCGAAAAGGG
CCACGGATCGTCGCGCAATTCGCCGGTGGTGATCCGATCGGTGCGCCGGCATGGCCGGCCTGGACGCCCGCGCCGCTGCG
GACGCGGTGGCCGGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8840.98 Da
• Isoelectric Point: 4.1813

>AT152491 WP_188346829.1 NZ_CP050303:233579-233821 [Phyllobacterium sp. 628]
MRVTVKKWGNSASVRIPAAIMAAAQLELDTTVDVREQDGLIIIEPVRQTEYNLDQLIEGVTPENIHSEADFGEAIGKETF

Nucleotide

• Length: 243 bp

>AT152491 NZ_CP066218:c3120711-3120319 [Mycolicibacterium sp. LJ126]
ATGGCTGATGTCGCCGACCGGGTGACCCGCGTCGCCGCAGACCTGATCGAGAGCGCGGCGGCCGAGGGTGCGCGTCAGAG
CCGCTCGGCCAAACAGCAACTCGACCACTGGGCGCGAGTCGGTCGCGCCGTCTCCAGCCATCACACGGCCGCTCGTCGGC
GGGTGGAAGCCGCCCTGGCGGGAGAGGCCGACCTGAGCACCTTGACCTCCGAAGAGGGCGTCGTCTTCAACGCCGAGATC
TCCGCGGCCATCGAGGAGCAACTCGCCGGCGCCGACTACGGAAACCTCCTTGCTGCGCAAGGGGTCACCACCGTCGCGCT
CGATGAGGAAGGGCGGATCGTGCAGTACCGGCCCGACGGCACGTCGGTCGTCCTCGACGACACATCGGCCTGA