Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2125845..2126452 Replicon chromosome
Accession NZ_CP050301
Organism Phyllobacterium sp. 628

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HB779_RS12040 Protein ID WP_188342636.1
Coordinates 2125845..2126150 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HB779_RS12045 Protein ID WP_188345900.1
Coordinates 2126144..2126452 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB779_RS12020 2121352..2121882 + 531 WP_188342633.1 NAD(P)H-dependent oxidoreductase -
HB779_RS12025 2121984..2122826 + 843 WP_188342634.1 DMT family transporter -
HB779_RS12030 2122829..2123476 - 648 WP_188342635.1 glutathione S-transferase family protein -
HB779_RS12035 2123653..2125764 + 2112 WP_188345899.1 molybdopterin oxidoreductase family protein -
HB779_RS12040 2125845..2126150 + 306 WP_188342636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB779_RS12045 2126144..2126452 + 309 WP_188345900.1 putative addiction module antidote protein Antitoxin
HB779_RS12050 2126458..2127069 - 612 WP_188345901.1 phosphoribosylglycinamide formyltransferase -
HB779_RS12055 2127078..2128139 - 1062 WP_188342637.1 phosphoribosylformylglycinamidine cyclo-ligase -
HB779_RS12060 2128557..2129105 + 549 WP_188342638.1 CDP-alcohol phosphatidyltransferase family protein -
HB779_RS12065 2129086..2130261 + 1176 WP_188342639.1 AI-2E family transporter -
HB779_RS12070 2130296..2130988 + 693 WP_188342640.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-90)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.44 Da        Isoelectric Point: 9.9289

>T152489 WP_188342636.1 NZ_CP050301:2125845-2126150 [Phyllobacterium sp. 628]
MKEFLETEAFTKWFDALRDRRARVRIVERLRRLSGGNPGDVKAVGEGVSELRIDYGSGYRVYFWDCGNILIILLCGGDKA
TQDRDIKRAKILAREFKEHRS

Download         Length: 306 bp

>T152489 NZ_CP066218:1051251-1051685 [Mycolicibacterium sp. LJ126]
TTGACGCCGGCGCCGGTGACGGCGGTCGATACTAGCGTCGCGGTGCCCCTCCTCGTGACCTCGCACCCTCAACACGCCCT
GATCGCGAAGTGGGCGAAGGCGCGGTCTCTCGGGCTCAGCGGGCACGCGTTGGCCGAAACCTACTCAGTGCTCACCCGCC
TGCCTGCCGACGCTCGCGTCAGCCCTCCTGACGCGGTCGCACTGATCGACGAGAACTTCCCCGAATCCTTTCAACTCGGC
GCCCGGGCCGCGCGTAACGCCCACCGCGAGTTCGCCCGGCGAGGAATCGCCGGGGGCGCGACCTATGACGGGCTTGTGGC
CTTGGCCGCTCGTGAGCGCGGCGCCGTGCTGTTCACCCGAGATGCGCGCGCAAGATCAACGTACGAAACACTCGGGGTGA
GCACGGAAGTGCTGGCAGACGGCTCCGAACCATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10863.64 Da        Isoelectric Point: 9.5492

>AT152489 WP_188345900.1 NZ_CP050301:2126144-2126452 [Phyllobacterium sp. 628]
IMIKLRKFDPARYLDSENMIEEYLLAACEGGDASHIARVLGDIARARGIAELARKTGLTRQALYKALSGEGNPGLATITK
VADALGLKLSLVPATPKKQDAA

Download         Length: 309 bp

>AT152489 NZ_CP066218:1051015-1051254 [Mycolicibacterium sp. LJ126]
ATGGAGGCTGTCATTGACTCCGGTGGTCGAATCGTCCTGCCCAAGCAGTTGCGTGATGCGCTGGGTCTGACTCCCGGATC
CACAGTGGATATCTCCGCGTATGGCGGTGGGCTGCACGTCATTCCCGGAGGGCGGACGGCTCGACTCGAGCGGGATGAGG
ACGGGCGCCTGGTCGCGAGGGCGGATACCGTCGTCACCGATGAGATGATGTTCGCCCTCATCGATTCGGGACGGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References