Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1560590..1561176 Replicon chromosome
Accession NZ_CP050301
Organism Phyllobacterium sp. 628

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HB779_RS09205 Protein ID WP_188345411.1
Coordinates 1560590..1560850 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HB779_RS09210 Protein ID WP_188345412.1
Coordinates 1560847..1561176 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB779_RS09185 1556477..1557973 + 1497 WP_188345407.1 catalase -
HB779_RS09190 1558088..1559377 + 1290 WP_188345408.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
HB779_RS09195 1559426..1559884 + 459 WP_188345409.1 tryptophan-rich sensory protein -
HB779_RS09200 1559886..1560530 + 645 WP_188345410.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase -
HB779_RS09205 1560590..1560850 + 261 WP_188345411.1 type II toxin-antitoxin system HicA family toxin Toxin
HB779_RS09210 1560847..1561176 + 330 WP_188345412.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HB779_RS09215 1561430..1562993 + 1564 Protein_1530 glutamine-hydrolyzing GMP synthase -
HB779_RS09220 1563286..1564542 + 1257 WP_188345413.1 site-specific integrase -
HB779_RS09225 1564496..1564792 - 297 WP_188345414.1 AlpA family phage regulatory protein -
HB779_RS09230 1565688..1565852 + 165 WP_188345415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1541762..1614612 72850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9474.97 Da        Isoelectric Point: 10.8992

>T152487 WP_188345411.1 NZ_CP050301:1560590-1560850 [Phyllobacterium sp. 628]
MKLSRKHQATLAAIFAEPVQAGIVWRDIEALFVACGADVTEGQGSRVRVALNGARAVFHRPHPQKETDKGAVKSVRRFLL
EAEIRP

Download         Length: 261 bp

>T152487 NZ_CP066218:92757-93050 [Mycolicibacterium sp. LJ126]
GTGAATCGGGTCGTCTTCTCGCCGGCGGCCCAGGTTGATTTGGAACAGATCTGGGACTGCACCTGCGACCGCTGGGATGC
CGATCAGGCGGAAAGATACATCCGCGTTCTTCAGCGTGCAGTCGAGCGTGTCGCGGACAATCCTTTGATCGGTCGCGCGT
GTGACGAGGTTCGGGTCGGGTACCGCCGGCATGCCGTGGGGTCACACACGTTGTACTACCGCGTCGCTGGCGACCTCATC
GTCGTGGTGCGCGTGCTACACAAACGCATGGACGTAGATCAGCACCTCGACTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12020.54 Da        Isoelectric Point: 4.8838

>AT152487 WP_188345412.1 NZ_CP050301:1560847-1561176 [Phyllobacterium sp. 628]
MNTMHYKGYEAVIEFDEDAGLFHGEVINLRDVITFQGSSAAQLKEALAGSVDDYLAFCTERGEEPEKPFSGQFVVRTEPL
LHKAISSAARRAGVSLNKWVVTTLERSLG

Download         Length: 330 bp

>AT152487 NZ_CP066218:92509-92760 [Mycolicibacterium sp. LJ126]
ATGGGTAAGAACACCTCGTTCAGCCTGGACACTCACTTCAATGAGTTCATCGAGGGCGAGGTTGCCTCAGGCCGGTACGG
CTCCGCCAGCGAGGTGGTGCGCGCCGCGTTGCGACTCCTCGAGGATCGCGAAACGCGCCTCGATGCGCTGCGCCAGGCCC
TGGGACGCGGCGAAAATAGTGGTGAGGCAACGGCCATCGACTTCGACGCGTTCGTAGAGCGAAAGGCCGTGGAATCGCGC
GCAGCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References