Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 651495..652972 Replicon plasmid p_1
Accession NZ_CP050299
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag HB778_RS40850 Protein ID WP_183455084.1
Coordinates 651495..652748 (-) Length 418 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag HB778_RS40855 Protein ID WP_183455083.1
Coordinates 652745..652972 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS40825 647664..647867 + 204 Protein_599 hypothetical protein -
HB778_RS40830 648009..648510 + 502 Protein_600 transposase -
HB778_RS40835 648792..650699 + 1908 WP_183465722.1 DDE-type integrase/transposase/recombinase -
HB778_RS40840 650833..650976 + 144 WP_183455085.1 hypothetical protein -
HB778_RS40845 651068..651229 - 162 Protein_603 IS110 family transposase -
HB778_RS40850 651495..652748 - 1254 WP_183455084.1 type II toxin-antitoxin system HipA family toxin Toxin
HB778_RS40855 652745..652972 - 228 WP_183455083.1 helix-turn-helix domain-containing protein Antitoxin
HB778_RS40860 653356..654498 - 1143 WP_183455464.1 IS630 family transposase -
HB778_RS40865 654903..655205 - 303 WP_210308095.1 transposase -
HB778_RS40870 655472..655693 - 222 WP_183459435.1 hypothetical protein -
HB778_RS40875 655690..656463 - 774 WP_183465277.1 IS21-like element helper ATPase IstB -
HB778_RS40880 656456..657955 - 1500 WP_183459433.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..686467 686467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(145-350)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 418 a.a.        Molecular weight: 45352.00 Da        Isoelectric Point: 6.0704

>T152485 WP_183455084.1 NZ_CP050299:c652748-651495 [Mesorhizobium huakuii]
MTHLLDVYFRETKAGILSQDEDGALGYAYYADYLAGQQPRVISFSMPLREEPYADRVARPFFSGLLPDEGARQRLAGALG
LSAGNAFGLLEVIGGECAGALSLYPAGEAPAPSDDDEALSAERLKEIIGKLRERPLLGGEEGVRLSLAGAQDKLAVIVEG
ETIRLAKGGRPTTHILKPVIQALEGTVENELFCLRLAERLQLPVPRVEMRRAGDTAFLLIQRYDRARTDGGHIERLHQED
FCQALSVPPELKYEEEGGPGTKSSLDLIDRACARPAADRLRFIRMLIFHYLVGNADAHGKNYALLYDGDTPNLAPLYDVV
CTAAYPRLAKKLAMAIGGRSVPDTIQLKHWLTLVPETRGAQRLLIRDIATMAGRIGDEADALLAQLANVGADHAILKSVR
AVIATRATHLLRMTEGG

Download         Length: 1254 bp

>T152485 NZ_CP066215:218955-219221 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8131.33 Da        Isoelectric Point: 11.3766

>AT152485 WP_183455083.1 NZ_CP050299:c652972-652745 [Mesorhizobium huakuii]
MQTITDSKTLGLRIRQERKSQGLTQEQLAGLTGVGVRFVRELEAGKETCQLGRALQVASALGLFLSVGRRRDSGS

Download         Length: 228 bp

>AT152485 NZ_CP066215:218692-218955 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References