Detailed information of TA system TA152484

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 634898..635496
• Replicon: plasmid p_1
• Accession: NZ_CP050299
• Organism: Mesorhizobium huakuii strain 583

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HB778_RS40755
• Protein ID: WP_183465715.1
• Coordinates: 634898..635191 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HB778_RS40760
• Protein ID: WP_183455093.1
• Coordinates: 635188..635496 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB778_RS40705	630065..630202	+	138	WP_183465927.1	type IV secretory system conjugative DNA transfer family protein	-
HB778_RS40710	630578..630823	+	246	WP_183465712.1	WGR domain-containing protein	-
HB778_RS40715	630943..631221	+	279	WP_183455100.1	HU family DNA-binding protein	-
HB778_RS40720	631259..631696	-	438	WP_183455099.1	PIN domain-containing protein	-
HB778_RS40725	631693..631920	-	228	WP_183455098.1	ribbon-helix-helix domain-containing protein	-
HB778_RS40730	631941..632117	-	177	WP_183465713.1	hypothetical protein	-
HB778_RS40735	632188..632499	-	312	WP_183455095.1	DUF736 domain-containing protein	-
HB778_RS40740	633201..633587	-	387	WP_183465714.1	type II toxin-antitoxin system VapC family toxin	-
HB778_RS40745	633584..633829	-	246	WP_183455096.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
HB778_RS40750	633945..634256	-	312	WP_183455095.1	DUF736 domain-containing protein	-
HB778_RS40755	634898..635191	-	294	WP_183465715.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HB778_RS40760	635188..635496	-	309	WP_183455093.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HB778_RS40765	635708..636634	-	927	WP_183465716.1	DUF1738 domain-containing protein	-
HB778_RS40770	636969..637556	-	588	WP_183465717.1	hypothetical protein	-
HB778_RS40775	637794..638294	+	501	WP_183465718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..686467	686467

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-57)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10886.37 Da
• Isoelectric Point: 6.0723

>T152484 WP_183465715.1 NZ_CP050299:c635191-634898 [Mesorhizobium huakuii]
MRLKWSAFALADRDDIFTHIEAESSRAAAAVDEHIAQAVLRLVEFPESGRPGRVPGTRELVISRTPYIAAYVLTHDAIRI
LRVLHGAQMWPEDFSSD

Nucleotide

• Length: 294 bp

>T152484 NZ_CP066203:c1987046-1986639 [Methylacidimicrobium sp. B4]
ATGAAGATCCTCCTGGACACCCAATGCTGGCTCTGGATGGAAGCCGAGCCGGAACGCTTGAATCCGCAGGTGAGGGATCT
TCTCCTCGATCCGGCCCACGCGCTCTACCTCTCCGCCGCAAGCGCTTGGGAAATCTCGATCAAGATCGCGATCGGAAAGC
TCCGGCTCCCCTCGCCGCCCTCGGCCTATCTCGCGGAACGGATGGGCCGAGAGAAGCTTCGTCCCCTCTCCATTGAGCAT
GAGCACGCGCTGCTCGCTGGCAGCCTGCCCCCGCACCACAGGGATCCTTTCGACCGGATGCTCGTTGCCCAGGCCCTTCG
GGAAAAGCTCACGCTCTTGAGCGCGGATCCGATCTTCGCGCGTTACGAAGCGGCAGTGCTCTGGGCGGACCGTGAGAGCA
GCCGCTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11096.48 Da
• Isoelectric Point: 5.6994

>AT152484 WP_183455093.1 NZ_CP050299:c635496-635188 [Mesorhizobium huakuii]
MATNALVQTRIDSNIRDRAASVLEGMGLTVSDVVRILLTRTANEGALPLELISNSEAHDAWFRAKVMQALEDTRTDVTAE
DVETHFASRRAAALRKAGTTQS

Nucleotide

• Length: 309 bp

>AT152484 NZ_CP066203:c1987276-1987043 [Methylacidimicrobium sp. B4]
ATGCAGACCGTGACCGTCCATGAAGCAAAGACCCACCTCTCTCGGCTATTGCGAAAAGTAGCGGGGGGCGAAGAGGTTCT
CGTCCTGCGGGGCAAAGTTCCGATCGCCAAGATCGTCCCCTTGGACATCGATCACGCCCCGCGCCGCCTCGGGCTCGACA
AGGGCAGGATTTGGATCGCCCCCGATTTCGACGCCCCTCTCCCCGAGGAGGTCCTTCGGGCCTTCGAGCCATGA