Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 631259..631920 Replicon plasmid p_1
Accession NZ_CP050299
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB778_RS40720 Protein ID WP_183455099.1
Coordinates 631259..631696 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB778_RS40725 Protein ID WP_183455098.1
Coordinates 631693..631920 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS40690 626697..627219 + 523 Protein_572 ISNCY family transposase -
HB778_RS40695 627520..628098 - 579 WP_183465711.1 helix-turn-helix domain-containing protein -
HB778_RS40700 628367..629998 + 1632 WP_183463841.1 transposase -
HB778_RS40705 630065..630202 + 138 WP_183465927.1 type IV secretory system conjugative DNA transfer family protein -
HB778_RS40710 630578..630823 + 246 WP_183465712.1 WGR domain-containing protein -
HB778_RS40715 630943..631221 + 279 WP_183455100.1 HU family DNA-binding protein -
HB778_RS40720 631259..631696 - 438 WP_183455099.1 PIN domain-containing protein Toxin
HB778_RS40725 631693..631920 - 228 WP_183455098.1 ribbon-helix-helix domain-containing protein Antitoxin
HB778_RS40730 631941..632117 - 177 WP_183465713.1 hypothetical protein -
HB778_RS40735 632188..632499 - 312 WP_183455095.1 DUF736 domain-containing protein -
HB778_RS40740 633201..633587 - 387 WP_183465714.1 type II toxin-antitoxin system VapC family toxin -
HB778_RS40745 633584..633829 - 246 WP_183455096.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HB778_RS40750 633945..634256 - 312 WP_183455095.1 DUF736 domain-containing protein -
HB778_RS40755 634898..635191 - 294 WP_183465715.1 type II toxin-antitoxin system RelE/ParE family toxin -
HB778_RS40760 635188..635496 - 309 WP_183455093.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HB778_RS40765 635708..636634 - 927 WP_183465716.1 DUF1738 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..686467 686467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15253.37 Da        Isoelectric Point: 6.8420

>T152483 WP_183455099.1 NZ_CP050299:c631696-631259 [Mesorhizobium huakuii]
VTFLLDVNVLIALIDPGHVAHDDAHGWFEVTGYAAWATCPITENGVLRIVGNQKYPNSPGSPAVVAQIVTKLRALHGHSF
WPDDVSLVGSGDIDAAKILTSAQVTDTYLLALAKAHGGQLASFDRKLSAAALKSGKSSLHLITTS

Download         Length: 438 bp

>T152483 NZ_CP066203:1919228-1920166 [Methylacidimicrobium sp. B4]
ATGCCACGTAAACCTCGAAATGTCGGCGCATCAGTACGGGCGCGACTCCTCGATCGGGCGCGCGTCCAGCGGTCTGACTT
TCAGATTTTGCTGACGCGCTACGCGCTCGAGCGTCTGCTGTACAGGCTGAGCATTTCAGGGCATCGCGACCGCTTCGTCC
TCAAAGGCGCAATGCTCTTTGTAACCTGGGTTGCCGATCTGTTCCGGTCGACCCGCGATCTCGATCTACTCGGCTACGGG
GACAATGAAGCCAAGGCGATCGCTGAGACTTTCCGCGCCATCTGTGCCCAGCCGGTCACCGATGACGGTGTCGTATTCGA
TGTCGCCGGGCTGGAGGCAGCGCCGATCCGTGAGGAGGGAGAATATGGCGGCGTGAGGGTGCGCGCGAGCGCTACTATCG
ATGGTGCGCGGATCCCGATCCGGGTCGATATCGGCTTCGGCGATGCCATCACCCCGGCACCGGTCGAAATCGATTACCCC
GCTTTGCTGGACGCACCCGCGCCGCATCTTCGGGCCTATCCCGTCGAGACGGTCGTGGCGGAGAAGTTCGAGGCGTTGGT
TACGCTCGGTATGGCCAACAGTCGTCTCAAGGATTTCTACGACCTTTGGCTGATCGCGCAGACATTCGAGTTTCATGAGT
CAACTCTTGTAGAAGCTGTGCGATGCACGTTCGAACGGCGTGCGACGAAGCTGCCGGTCGATATCCCGATCGGCCTGAGC
GATGAATTCGCGGAGGCATGGGGCGCTCAATGGCAAACCTTCCTGGGGCGTGAGCGCATGACTGCCGTACCTGGCGCGTT
TTCCGCCGTCATCGCCGATCTAGGGGCCTTCCTGATTCCGTTAGCAGGTGCGGCCGAAGACGGGCGGGTGTGGCTTCCTG
GCGGACCATGGTTGCAACCAGCTTCTTCGACTGATGCAAATGAAATGAAAAGCGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8186.36 Da        Isoelectric Point: 6.2820

>AT152483 WP_183455098.1 NZ_CP050299:c631920-631693 [Mesorhizobium huakuii]
MRTTLAIDDDVLVAAKAMARQQDRSVGEIITDLARRSLRRPQAGGERNGIPLLSPRPDAPPVTLETVNALRDELP

Download         Length: 228 bp

>AT152483 NZ_CP066203:1918618-1919238 [Methylacidimicrobium sp. B4]
ATGACCTCGATTAGCGCCCAACGGACCCGTGCCCTTGATCTCCTGAAAACCCGGGGAATGCTCCGGCTGAAGGATTTCGT
TGCGGAAGGGATCGGACCGGAGACGCTGGCCCGTCTCATGCGGGAGAAGGCGGTCGTGCGTCCAGCCCGGGGCCTTTATC
AGCTCCTAGACGCGCAGATCGAGGCCGCCCACATGCTCGCCGAAGCCGCGGTCCTGGTTCCCAAGGGTGTCGTCTGCCTG
ACCTCGGCGCTCCAGTTCCATGAACTGACGCTGCAGATGCCGTCTGCCGTATGGATGGCAATCGAACGGACCGCTTGGCG
GCCCAGAATCGATTATCCGCGAATCCGCTTTGTGCGTTTCACCGGGGCAGCGCTGACCGAGGGCATTACCCGCCACCGCA
TTGAGAGTACCAACGTCCCCATCACGGATCCGGCCAGGACGGTCGTGGACTGCTTCCGCTATCGGGCCAAGGTCGGTCTC
GACGTCGCGATGGAAGGGCTGCGCGAGGGCCTTCGCCGTCGCCGCTGCACGCCCGACGAACTCTGGCGTTACGCGCGGAA
GGCTCGAGTCTGGTCGGTGATGCGCCCCTACGTCGAAGCGATGGCAGCCGATGCCACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References