Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 615821..616416 Replicon plasmid p_1
Accession NZ_CP050299
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HB778_RS40630 Protein ID WP_183455110.1
Coordinates 615821..616009 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HB778_RS40635 Protein ID WP_183455109.1
Coordinates 616015..616416 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS40610 611360..612417 + 1058 Protein_556 P-type DNA transfer ATPase VirB11 -
HB778_RS40615 612395..614530 + 2136 WP_183465706.1 type IV secretory system conjugative DNA transfer family protein -
HB778_RS40620 614675..615193 - 519 WP_183465707.1 GNAT family N-acetyltransferase -
HB778_RS40625 615190..615465 - 276 WP_183455111.1 DUF1778 domain-containing protein -
HB778_RS40630 615821..616009 + 189 WP_183455110.1 type II toxin-antitoxin system HicA family toxin Toxin
HB778_RS40635 616015..616416 + 402 WP_183455109.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HB778_RS40640 616829..619156 - 2328 WP_183465708.1 relaxase/mobilization nuclease domain-containing protein -
HB778_RS40645 619153..619569 - 417 WP_183455107.1 hypothetical protein -
HB778_RS40650 620125..620826 + 702 WP_183465709.1 ParA family protein -
HB778_RS40655 620823..621254 + 432 WP_183465710.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..686467 686467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-123)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6975.10 Da        Isoelectric Point: 11.1468

>T152482 WP_183455110.1 NZ_CP050299:615821-616009 [Mesorhizobium huakuii]
MKSAAVIQALEADGWYEVARKGSHAQFKHEKKPGRVTVPHPKRDIPLGTLRSIERQSGLKLR

Download         Length: 189 bp

>T152482 NZ_CP066203:c1172346-1172068 [Methylacidimicrobium sp. B4]
ATGGCATGGAGGGTTGAGCTATCCACCCTGGCACGGAAAACTCTGGAGAAGCTCGACCCACCGATTGCCCGGCGCATCCT
CCTTTTTCTTCACGAGCGTGTTGCACCACTCGACGATCCGCGAGGCATAGGGGAGCGCCTCCAAGGTCCCCGCTTCGGAG
AGCTTTGGCGCTATCGAGTAGGCGATTACCGCCTGATCGCAAAGATCGAGGATGGCGCTTTACGTATTCTTGTCCTTCTC
ATCGGTCACCGCCGCAACATCTACCGGAAGCAGCCCTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14274.05 Da        Isoelectric Point: 4.2543

>AT152482 WP_183455109.1 NZ_CP050299:616015-616416 [Mesorhizobium huakuii]
MKQYIGLIHKDAESDFGVSFPDFPGVVTAGTDLDDARAMAEEALAFHIEGLAEDGEAIPEPSSLENVMADAENRRGVAIL
VAVKTEAKKAVRVNVTLPEDVLNRIDAFAEAHGYTRSGFIAQATQKVMELEAA

Download         Length: 402 bp

>AT152482 NZ_CP066203:c1172557-1172330 [Methylacidimicrobium sp. B4]
ATGCCTTTATCCGTCCGCCTCCCAGGTGATCTTGAGTCTCGACTGCAAAACCTCGCCGATAGGACTGGCCGCAGCAAAAC
CTATTATGTGATCGAAGCCATTCGAGAATACATCGAGGTTATGGAGGATATCTACTTGGCGGAAGGAGAGATCGAGGCGA
TGCGCGCAGGGAGGTCAGAAGCTCTGCCACTGGAAGAAGTGATGAAACATTATGGCATGGAGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References