Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5684927..5685537 Replicon chromosome
Accession NZ_CP050296
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HB778_RS27460 Protein ID WP_183458502.1
Coordinates 5685349..5685537 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HB778_RS27455 Protein ID WP_183458500.1
Coordinates 5684927..5685325 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS27435 5681129..5682187 + 1059 WP_183458498.1 glycerophosphodiester phosphodiesterase family protein -
HB778_RS27440 5682275..5683657 + 1383 WP_183465245.1 MFS transporter -
HB778_RS27445 5683721..5684203 - 483 WP_027042360.1 30S ribosomal protein S9 -
HB778_RS27450 5684205..5684669 - 465 WP_010915638.1 50S ribosomal protein L13 -
HB778_RS27455 5684927..5685325 - 399 WP_183458500.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HB778_RS27460 5685349..5685537 - 189 WP_183458502.1 type II toxin-antitoxin system HicA family toxin Toxin
HB778_RS27465 5685585..5686034 - 450 WP_183458504.1 PaaI family thioesterase -
HB778_RS27470 5686189..5687010 + 822 WP_183458506.1 enoyl-CoA hydratase -
HB778_RS27475 5687013..5687435 + 423 WP_183458508.1 VOC family protein -
HB778_RS27480 5687435..5688217 + 783 WP_095201542.1 AAA family ATPase -
HB778_RS27485 5688214..5688981 + 768 WP_183458509.1 GNAT family N-acetyltransferase -
HB778_RS27490 5688978..5689499 + 522 WP_095201541.1 CoA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7045.27 Da        Isoelectric Point: 10.8889

>T152480 WP_183458502.1 NZ_CP050296:c5685537-5685349 [Mesorhizobium huakuii]
MLERDSRKIIKRLKEDGFELISIRGSHHKFRKGEIVLIVPHPEKDLPTGTARAIAKQAGWIG

Download         Length: 189 bp

>T152480 NZ_CP050296:c5685537-5685349 [Mesorhizobium huakuii]
TTGCTTGAGCGTGACAGCCGTAAGATCATAAAGCGCCTCAAGGAGGACGGGTTCGAGCTGATTTCGATACGCGGCTCGCA
CCACAAATTCCGGAAGGGCGAGATCGTGTTGATTGTTCCGCATCCCGAAAAAGACCTGCCCACTGGCACTGCTCGTGCGA
TCGCCAAGCAAGCTGGTTGGATCGGATAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14222.14 Da        Isoelectric Point: 4.6173

>AT152480 WP_183458500.1 NZ_CP050296:c5685325-5684927 [Mesorhizobium huakuii]
MKNYFALVEKDPDSAFGIRFPDIPGCFSAADTAEDIVPNAVEALQLWAEDMPVPKPSSHEAIVALPDIRTALAEGGYLVS
VPLIDNDSAVVRANVTFERGVLRAIDAAARERGITRSAFLSSAARKEIEAKH

Download         Length: 399 bp

>AT152480 NZ_CP050296:c5685325-5684927 [Mesorhizobium huakuii]
ATGAAGAACTATTTCGCCTTGGTCGAGAAAGACCCCGACAGCGCGTTCGGTATTCGCTTTCCCGACATTCCCGGCTGTTT
TTCGGCCGCGGATACGGCCGAAGACATCGTACCCAATGCGGTTGAAGCCTTGCAATTGTGGGCGGAGGATATGCCGGTTC
CAAAGCCGTCCAGCCACGAAGCGATTGTCGCCCTCCCCGACATACGCACCGCGCTTGCCGAAGGCGGCTATCTGGTCTCG
GTGCCGCTCATCGACAATGACAGCGCGGTCGTGAGGGCGAATGTGACTTTCGAACGTGGCGTCCTGCGGGCGATCGACGC
AGCGGCACGGGAGCGTGGCATTACGCGATCAGCATTCCTTTCCAGCGCGGCTCGCAAGGAAATCGAGGCAAAGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References