Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3139141..3139814 Replicon chromosome
Accession NZ_CP050296
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB778_RS15525 Protein ID WP_183464636.1
Coordinates 3139141..3139563 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB778_RS15530 Protein ID WP_183465102.1
Coordinates 3139560..3139814 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS15495 3134405..3135331 - 927 WP_183464630.1 ABC transporter permease -
HB778_RS15500 3135328..3136413 - 1086 WP_183464631.1 ABC transporter ATP-binding protein -
HB778_RS15505 3136490..3137530 - 1041 WP_183464632.1 ABC transporter substrate-binding protein -
HB778_RS15510 3137771..3138472 + 702 WP_183464633.1 GntR family transcriptional regulator -
HB778_RS15515 3138487..3138666 - 180 WP_183464634.1 hypothetical protein -
HB778_RS15520 3138798..3139124 - 327 WP_183464635.1 hypothetical protein -
HB778_RS15525 3139141..3139563 - 423 WP_183464636.1 type II toxin-antitoxin system VapC family toxin Toxin
HB778_RS15530 3139560..3139814 - 255 WP_183465102.1 plasmid stabilization protein Antitoxin
HB778_RS15535 3139948..3140478 - 531 WP_183464637.1 dihydrofolate reductase family protein -
HB778_RS15540 3141160..3141161 - 2 WP_183464546.1 IS630 family transposase -
HB778_RS15545 3141987..3143297 + 1311 WP_183464638.1 site-specific integrase -
HB778_RS15550 3143348..3143536 - 189 WP_183464639.1 hypothetical protein -
HB778_RS15555 3143533..3144249 - 717 WP_183464640.1 hypothetical protein -
HB778_RS15560 3144398..3144625 + 228 WP_210308082.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14884.91 Da        Isoelectric Point: 4.4186

>T152478 WP_183464636.1 NZ_CP050296:c3139563-3139141 [Mesorhizobium huakuii]
MIVLDTNIVSEAMKPEPAPAVRDWLDEQAAETLYLSSVTVAELVFGIGALPDGRRKQNLATTLDGLLDLFDGRILPFDTD
AARRYADLAVAARDSGRGFPTPDGYIAAIAVAHGFVVATRDASAFKAAGVPVIDPWKTGQ

Download         Length: 423 bp

>T152478 NZ_CP066194:c1398166-1397816 [Bacillus cytotoxicus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCAGCGATTACTGCACAGATTCAAAAAG
CAAAATTGCCCACGCATGTGGAGATTGATGCGAAGAAGTACGGATTTGAGAGAGATTCTGTGATCTTGCTCGAGCAGATT
CGAACAATTGATAAGCAACGCTTAACGGACAAAATCACACATTTAGATGAAGTGATGATGATTCGTGTAGATGAGGCTTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9239.45 Da        Isoelectric Point: 6.7263

>AT152478 WP_183465102.1 NZ_CP050296:c3139814-3139560 [Mesorhizobium huakuii]
MPAVTIRNLSEEAHRALKLRAAHHGRSTEAEMRELLEAAVRPANRILIGSAMSALSRSAGLTNADFEPLEQDRDRTPATP
MSFE

Download         Length: 255 bp

>AT152478 NZ_CP066194:c1398458-1398171 [Bacillus cytotoxicus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAGTGGTGACGGAATTGGACGGGATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAAAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References