Detailed information of TA system TA152477

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 2471533..2472080
• Replicon: chromosome
• Accession: NZ_CP050296
• Organism: Mesorhizobium huakuii strain 583

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HB778_RS12185
• Protein ID: WP_183464102.1
• Coordinates: 2471533..2471826 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HB778_RS12190
• Protein ID: WP_183464104.1
• Coordinates: 2471826..2472080 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB778_RS12150	2467066..2467935	+	870	WP_183464094.1	endonuclease/exonuclease/phosphatase family protein	-
HB778_RS12155	2467943..2468476	-	534	WP_183465066.1	GNAT family N-acetyltransferase	-
HB778_RS12160	2468498..2469085	-	588	WP_183464096.1	GNAT family N-acetyltransferase	-
HB778_RS12165	2469205..2469474	-	270	WP_010912120.1	50S ribosomal protein L27	-
HB778_RS12170	2469573..2470256	-	684	WP_183464098.1	50S ribosomal protein L21	-
HB778_RS12180	2471081..2471497	+	417	WP_183464100.1	hypothetical protein	-
HB778_RS12185	2471533..2471826	-	294	WP_183464102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HB778_RS12190	2471826..2472080	-	255	WP_183464104.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HB778_RS12195	2472170..2473051	-	882	WP_183464106.1	LysR family transcriptional regulator	-
HB778_RS12200	2473163..2473891	+	729	Protein_2413	SDR family oxidoreductase	-
HB778_RS12205	2473894..2474169	+	276	WP_183464108.1	Atu4866 domain-containing protein	-
HB778_RS12210	2474261..2474635	+	375	WP_183464110.1	hypothetical protein	-
HB778_RS12215	2474727..2476184	-	1458	WP_183464112.1	autotransporter outer membrane beta-barrel domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (3-68)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11061.79 Da
• Isoelectric Point: 6.3261

>T152477 WP_183464102.1 NZ_CP050296:c2471826-2471533 [Mesorhizobium huakuii]
VGFRLSLAAEDDIIAIAEQGVRLFGAAQARLYHEQLFAMLDLIAANPRMARERYEISPPMRIHPFKAHLVVYRIEADGDI
LIVRIRHGHEDWASDIL

Nucleotide

• Length: 294 bp

>T152477 NZ_CP066192:1972997-1973737 [Bacillus cytotoxicus]
TTGACTGTCACTAGCGTTCGAATTGGCTTGTTTTTTCTTGTAATCTTTTTTTTATTTCTTATTTTCTTTTATTGGAGAAA
TGAAGAACGATACGAGGAAAGAAAACAACTTATTCGAAAGACGTGGTATGGTTTATTTATTACATCAGTCACAATGTATT
TCATGATGAAAGGAATTGATTTAACCCTCTGGAAACATATTTTAATGGTTGTTGCGATGGTTGTATTTGTTGATATTGCA
TTTATTTTAACGCCAAATATTTCGGAAATCTGGGGCGCAAAGTTTAGTGATATTGGTAAGACAGTTCAATCGATTAAACG
ATCGCTTATTGCTTCAAAAGCAAGAGGAGAAATATATACAACACTTATTCAAAATGTAAATCCAGCTGCATTTGGTACGA
TGGAATGGGAAACAGATGCTGAGTATGCACGCAGTTTAAATGCTTTTCTTGATACGTATGCTGAAAAAATAGGTGCGAAA
ATTGTAGTATTTGTCACAGAAGAGGAATTAAATACAAACTTCCGAGGTGTTCGATCTCAATTTAGTATTACAGTATCACC
CGAATCTATTGAACAACTGAATGAGCAAAAAGCAGTTCAAATTGAAAATGTTGGAATTATACCAGCGAAAATAATAAAAG
ACGTTTATATTATTATGGATGGACAAAAAAATAATTTGCAAGATCGTGACTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTACTTTTGTAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9345.49 Da
• Isoelectric Point: 9.7301

>AT152477 WP_183464104.1 NZ_CP050296:c2472080-2471826 [Mesorhizobium huakuii]
MATMNVSLPDPMKDWVEAQTKTGRYANASDYVRDLIRRDQERNDKIAAMQRFVDDGLKSGIGTRSKDALFAEALTRANAP
RGNG

Nucleotide

• Length: 255 bp

>AT152477 NZ_CP066192:1973861-1973989 [Bacillus cytotoxicus]
GTGTTAAAAGAATATAGCAATGATTTCTTTAAAGACGAAGCTGAGGATACAACAGATTTTTCTTTAATAAAAGGAGATAC
AATGCAGCAAGTGGAAGAATTAGAAGAAGAATTGAAAAGAAGAGGATAA