Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1377831..1378456 Replicon chromosome
Accession NZ_CP050296
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB778_RS06920 Protein ID WP_183462551.1
Coordinates 1378070..1378456 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB778_RS06915 Protein ID WP_183462549.1
Coordinates 1377831..1378073 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS06890 1373711..1374637 + 927 WP_183465025.1 cation diffusion facilitator family transporter -
HB778_RS06895 1374819..1375922 - 1104 WP_183462541.1 hypothetical protein -
HB778_RS06900 1376018..1376455 + 438 WP_183462543.1 DsrE family protein -
HB778_RS06905 1376519..1377301 + 783 WP_183462545.1 SDR family oxidoreductase -
HB778_RS06910 1377366..1377674 + 309 WP_183462547.1 antibiotic biosynthesis monooxygenase -
HB778_RS06915 1377831..1378073 + 243 WP_183462549.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HB778_RS06920 1378070..1378456 + 387 WP_183462551.1 type II toxin-antitoxin system VapC family toxin Toxin
HB778_RS06925 1378537..1379640 + 1104 WP_183462553.1 AbrB family transcriptional regulator -
HB778_RS06930 1379664..1380743 - 1080 WP_183462555.1 siderophore-interacting protein -
HB778_RS06935 1380920..1381249 - 330 WP_183462557.1 hypothetical protein -
HB778_RS06940 1381345..1382232 - 888 WP_183462558.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(12-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14261.47 Da        Isoelectric Point: 4.6059

>T152476 WP_183462551.1 NZ_CP050296:1378070-1378456 [Mesorhizobium huakuii]
VKLLLDTHLLLWAASEPERLPLAALGEIENPDNELLFSPASLWEIAIKRGLGRDDFQVDPRLLRRGLFDSGYLELPITSE
HAVTIDGLPAVHKDPFDRILVAQAIVEGITLLTTDDLVARYPGPIRKF

Download         Length: 387 bp

>T152476 NZ_CP066192:318416-318766 [Bacillus cytotoxicus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCAGCGATTACTGCACAGATTCAAAAAG
CAAAATTGCCCACGCATGTGGAGATTGATGCGAAGAAGTACGGATTTGAGAGAGATTCTGTGATCTTGCTCGAGCAGATT
CGAACAATTGATAAGCAACGCTTAACGGACAAAATCACACATTTAGATGAAGTGATGATGATTCGTGTAGATGAGGCTTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8682.98 Da        Isoelectric Point: 10.0922

>AT152476 WP_183462549.1 NZ_CP050296:1377831-1378073 [Mesorhizobium huakuii]
MQTVNIHNAKTNLSRLVDRAAKGEPFIIAKAGKPLVKVVPIDQPASQARRVGFMAGQFSVPDDFDRMGSEDIEQLFGGKA

Download         Length: 243 bp

>AT152476 NZ_CP066192:318124-318411 [Bacillus cytotoxicus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAGTGGTGACGGAATTGGACGGGATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAAAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References